4985-46-0

Basic information

• Product Name: H-TYR-NH2 HCL
• Synonyms: (S)-2-AMino-3-(4-hydroxyphenyl)propanaMide;H-Tyr-NH2 Hydrochloride;(alphaS)-alpha-Amino-4-hydroxybenzenepropanamide;L-Tyr-NH2;L-Tyrosine amide≥ 98% (HPLC);TYROSINE-NH2;TYROSINE-NH2 HCL;TYROSINAMIDE
• CAS NO: 4985-46-0
• Molecular Formula: C₉H₁₂N₂O₂
• Molecular Weight: 216.66
• Product Categories: Amino Acids;I - Z;Modified Amino Acids
• Mol File: 4985-46-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 153.5°C
• Boiling Point: 313.03°C (rough estimate)
• Flash Point: 218.5 °C
• Appearance: /
• Density: 1.1819 (rough estimate)
• Vapor Pressure: 2.84E-08mmHg at 25°C
• Refractive Index: 1.5373 (estimate)
• Storage Temp.: -15°C
• PKA: 9.97±0.15(Predicted)
• CAS DataBase Reference: H-TYR-NH2 HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-TYR-NH2 HCL(4985-46-0)
• EPA Substance Registry System: H-TYR-NH2 HCL(4985-46-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 4985-46-0(Hazardous Substances Data)

Usage

Description

L-Tyrosine amide is a tyrosine derivative and chiral ligand that has been used in the in vitro selection of DNA aptamers for the development of aptamer-based biosensors.

Chemical Properties

White to off-white powder

Definition

ChEBI: An amino acid amide that is L-tyrosine in which the carboxy OH group is replaced by NH2.

InChI:InChI=1/C9H12N2O2/c10-8(9(11)13)5-6-1-3-7(12)4-2-6/h1-4,8,12H,5,10H2,(H2,11,13)/t8-/m0/s1

Upstream product

• 101469-25-4 tyrosinamide 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 556-02-5 ?Tyr 
• 60-18-4 L-tyrosine 
• 34081-17-9 tyrosine ethyl ester 
• 1080-06-4 L-Tyr-OMe 

Downstream Products

• 116055-06-2 N-trichloroacetyl-L-tyrosine amide 
• 96113-36-9 N-(S-benzyl-N-benzyloxycarbonyl-L-cysteinyl)-L-tyrosine amide 
• 7376-99-0 N-trifluoroacetyl-L-tyrosine amide 
• 15985-81-6 N-thiobenzoyl-L-tyrosine amide 
• 15985-84-9 N-phenylthioacetyl-L-tyrosine amide 
• 57851-59-9 N-(N-benzyloxycarbonyl-L-phenylalanyl)-L-tyrosine amide 
• 106-48-9 4-chloro-phenol 
• 76532-61-1 (S)-4-(4-hydroxy-benzyl)-2-thioxo-thiazolidin-5-one 
• 99437-67-9 (+/-)-4-(4-hydroxy-benzyl)-2-thioxo-thiazolidin-5-one 
• 1003005-60-4 N-((1E)-6-(2-furyl)hex-1-enyl)(2S)-2-amino-3-(4-hydroxyphenyl)propanamide 
• 1078141-17-9 (S)-2-((1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-ylamino)methyl)-5-methoxy-3-(4-nitrophenoxy)phenyl acetate 
• 1129669-12-0 C₂₂H₂₁N₃O₃ 
• 19790-44-4 Cbz-Gly-Tyr-NH₂ 
• 1593627-53-2 C₁₁H₁₃BrN₂O₃ 

Relevant articles and documents

Synthesis of aromatic amino acid amides

Aromatic amino esters, in toluene or water, react with aqueous ammonium hydroxide to give moderate to high yields of the corresponding amides.

Synthetic method for chiral alpha-aminoamide compounds

The invention provides a synthetic method for chiral alpha-aminoamide compounds, belongs to the technical field of organic synthetic methodology, and concretely relates to a synthetic method for chiral alpha-aminoamide compounds, wherein the method has a simple process, low costs and good economy. The method comprises the following steps: 1, performing ammonolysis: adding substituted chiral alpha-aminocarboxylate hydrochloride into concentrated ammonia water, performing stirring for 4-12h under a room temperature, wherein each 1mmol substituted chiral alpha-aminocarboxylate hydrochloride is corresponding to 2-8mL the concentrated ammonia water; 2, after a reaction is finished, performing distillation for removing ammonia water after the reaction to obtain crude products chiral alpha-aminoamide compounds; and 3, performing filtration on the obtained crude products chiral alpha-aminoamide compounds by adopting a manner of adding a solvent or performing purification on the obtained crude products chiral alpha-aminoamide compounds through a manner of column chromatography which uses ammonia water as a mobile phase to obtain the products chiral alpha-aminoamide compounds. Compared with the prior art, a large number of an ammonia gas for ammonolysis is not needed in the method, the process and post-treatment are simple, costs are low and reaction time is short.

Process for producing optically active alpha-amino acid and optically active alpha-amino acid amine

The present invention provides a process for efficiently producing an optically active α-amino acid and an optically active α-amino acid amide. After contacting with cells or processed cells thereof having an ability to asymmetrically hydrolyse, a water solvent is substituted with at least one solvent selected from the group consisting of linear, branched, or cyclic alcohol having 3 or more carbon atoms and the optically active α-amino acid is preferentially precipitated from the alcohol solution. The addition of basic compounds, particularly potassium compounds to the alcohol solution containing the optically active α-amino acid amide, which is obtained after the separation of the optically active α-amino acid, enables the purification of the amide without the inclusion of amino acid into amino acid amide. Thus, the amide is subjected to the step of racemization and then recycled.