48189-64-6

Basic information

• Product Name: N,N-dimethyl-N-{4-[2-(2-quinolinyl)vinyl]phenyl}amine
• Synonyms: N,N-dimethyl-N-{4-[2-(2-quinolinyl)vinyl]phenyl}amine;N,N-dimethyl-4-[(E)-2-(quinolin-2-yl)ethenyl]aniline
• CAS NO: 48189-64-6
• Molecular Formula: C₁₉H₁₈N₂
• Molecular Weight: 274.35962
• Mol File: 48189-64-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 451.7±24.0 °C(Predicted)
• Appearance: /
• Density: 1.152±0.06 g/cm3(Predicted)
• PKA: 5.08±0.24(Predicted)
• CAS DataBase Reference: N,N-dimethyl-N-{4-[2-(2-quinolinyl)vinyl]phenyl}amine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-N-{4-[2-(2-quinolinyl)vinyl]phenyl}amine(48189-64-6)
• EPA Substance Registry System: N,N-dimethyl-N-{4-[2-(2-quinolinyl)vinyl]phenyl}amine(48189-64-6)

Safety Data

• Hazardous Substances Data: 48189-64-6(Hazardous Substances Data)

Upstream product

• 91-63-4 2-methylquinoline 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 164118-85-8 (E)-1-[4-(dimethylamino)phenyl]pent-1-en-4-yn-3-ol 
• 615-43-0 2-iodophenylamine 
• 102081-11-8 2-[2]quinolyl-1-(4-dimethylamino-phenyl)-ethanol 

Downstream Products

• 3915-61-5 2-{(E)-2-[4-(dimethylamino)phenyl]ethenyl}-1-methylquinolinium iodide 
• 64-17-5 ethanol 

Relevant articles and documents

Use of nitrogen-containing heterocyclic radical substituted alkene compounds

The invention relates to new use of a series of nitrogen-containing heterocyclic radical substituted alkene compounds, and more specifically relates to use of the compounds represented by general formula a or salts thereof in bioimaging, pH value detection, biomacromolecule detection or cell microenvironment detection, wherein Z, S1, S2 and R1 are defined as the specification. The compounds are utilized as the fluorescent dye for bioimaging, fluorescent pH probe for pH value detection and/or diagnostic agent for tumor cell detection. The compounds involved in the invention have excellent imaging effect, and shows the single component multicolor property, can be used for single component multicolor imaging or conventional imaging, etc., and haves enormous application prospect in bioimaging and tumor detection. (formula a).

Design, synthesis, and biological evaluation of 2-arylethenylquinoline derivatives as multifunctional agents for the treatment of Alzheimer's disease

A series of new 2-arylethenylquinoline derivatives (4a1-4a12, 4b1-4b8, 4c1-4c4, 4d1-4d3 and 4e1-4e9) were designed, synthesized, and evaluated as potential multifunctional agents for the treatment of Alzheimer's disease (AD). In vitro studies showed that these synthetic compounds inhibited self-induced Aβ1-42 aggregation effectively ranged from 23.6% to 83.9% at the concentration of 20 μM, and acted as potential antioxidants and biometal chelators. Their structure-activity relationships were obtained and discussed. In particular, compound 4b1, the most active compound, displayed strong inhibitory activity with an IC50 value of 9.7 μM for self-induced Aβ1-42 aggregation, good antioxidative activity with a value of 3.9-fold of Trolox, potent inhibitory activity for cholinesterase with IC50 values of 0.2 μM and 64.1 μM against butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE), respectively. Besides, 4b1 was also capable of disassembling the self-induced Aβ1-42 aggregation fibrils with a ratio of 59.8% at 20 μM concentration, and had a good metal chelating activity. Taken together, these results suggest that compound 4b1 might be a promising lead compound for AD treatment.

Microwave-assisted solvent-free synthesis of 2-styrylquinolines in the presence of zinc chloride

An efficient solvent-free procedure has been developed for the synthesis of (E)-2-styrylquinoline derivatives under microwave irradiation in the presence of zinc chloride. The developed procedure is advantageous due to shorter reaction time and simpler wo