482295-82-9Relevant academic research and scientific papers
Molecular modeling based approach, synthesis, and cytotoxic activity of novel benzoin derivatives targeting phosphoinostide 3-kinase (PI3Kα)
Sabbah, Dima A.,Saada, Musaab,Khalaf, Reema Abu,Bardaweel, Sanaa,Sweidan, Kamal,Al-Qirim, Tariq,Al-Zughier, Amani,Halim, Heba Abdel,Sheikha, Ghassan Abu
supporting information, p. 3120 - 3124 (2015/07/08)
Abstract The oncogenic potential of phosphatidylinositol 3-kinase (PI3Kα) has made it an attractive target for anticancer drug design. In this work, we describe our efforts to optimize the lead PI3Kα inhibitor 2-hydroxy-1,2-diphenylethanone (benzoin). A s
Oxazoles Are Masked Carboxyls That Activate Ortho-Leaving Groups in Nucleophilic Aromatic Substitution
Cram, Donald J.,Bryant, Judi A.,Doxsee, Kenneth M.
, p. 19 - 22 (2007/10/02)
Oxazoles substituted in their 2-positions with 2-methoxy-, 2-fluoro-, or 2,6-difluorophenyl groups, and in their 4,5-positions with methyls or phenyls, were treated with ArMgBr or ArLi to give substituted biphenyl or terphenyl products.The oxazole groups were subsequently converted to esters, acids, or amides.These reactions provide a new unsymmetrical aryl-aryl coupling synthon.
