482375-84-8

Upstream product

• 53560-26-2 3-(3,4,5-trimethoxyphenyl)propan-1-ol 
• 124-63-0 methanesulfonyl chloride 
• 90-50-6 3,4,5-trimethoxycinnamic acid 

Downstream Products

• 91562-22-0 5-(3-iodopropyl)-1,2,3-trimethoxybenzene 
• 204510-72-5 (R,S)-1-methoxy-2-cyano-3-[3-(3,4,5-trimethoxyphenyl)propyl]cyclopentene 
• 204510-68-9 2-Oxo-5-[3-(3,4,5-trimethoxy-phenyl)-propyl]-cyclopentanecarbonitrile 

Relevant academic research and scientific papers

Unsymmetrical cyclic diamine compound

A cyclic diamine compound of formula (1): wherein A is (CH2)n, (CH2)n—CH═CH, CO—(CH2)n or CO—(CH2)n—CH═CH, in which n is a number of 0 to 3; Z represents a formula (2) or (3): in which R1, R2, R4, R5 and R6 are individually a hydrogen atom, alkyl group, alkoxy group, halogen atom or nitro group; R3 is a hydrogen atom, alkyl group, alkoxy group, halogen atom, nitro group, naphthyl group, or phenyl group which may be substituted by 1 to 3 substituents selected from the group consisting of alkyl groups, alkoxy groups, halogen atoms, a nitro group and a phenyl group; and X and Y are individually CH or a nitrogen atom; and m is 1 or 2; an acid-addition salt thereof, or a hydrate thereof, and a medicine containing such a compound.

2,4-diamino-6,7-dihydro-5?-cyclopentacf|pyrimidine analogues of trimethoprim as inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase

Three previously unreported (R,S)-2,4-diamino-5-[(3,4,5-trimethoxyphenyl)alkyl]-6,7-dihydro5.ff- cyclopenta[rf]pyrimidines 15a-c were synthesized as analogues of trimethoprim (TMP) and were tested as inhibitors of Pneumocystis carinii, Toxoplasma gondii,