482626-40-4

Upstream product

• 201993-96-6 (2R,3S)-3-Benzyloxymethoxy-5-(4-methoxy-benzyloxy)-2-methyl-pentanoic acid methoxy-methyl-amide 
• 374752-76-8 (2R,3S)-3-Benzyloxymethoxy-5-(4-methoxy-benzyloxy)-2-methyl-pentanal 
• 129985-91-7 <3(2R,3S),4R,5S>-3-<3-hydroxy-5-<(4-methoxyphenyl)methoxy>-2-methyl-1-oxopentyl>-4-methyl-5-phenyl-2-oxazolidinone 
• 152330-77-3 (2R,3S)-3-hydroxy-N-methoxy-5-(4-methoxybenzyloxy)-N,2-dimethylpentanamide 
• 128461-65-4 3-(p-methoxybenzyloxy)propanal 
• 67-56-1 methanol 
• 374753-00-1 (4S,5R)-3-[(2S,3R,4S,5S)-5-Benzyloxymethoxy-3-hydroxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-heptanoyl]-4-methyl-5-phenyl-oxazolidin-2-one 

Downstream Products

• 374753-02-3 (2S,3R,4S,5S)-5-Benzyloxymethoxy-3-hydroxy-2,4-dimethyl-7-triisopropylsilanyloxy-heptanoic acid methyl ester 
• 482626-41-5 (2S,3R,4S,5S)-5-Benzyloxymethoxy-3,7-dihydroxy-2,4-dimethyl-heptanoic acid methyl ester 

Relevant academic research and scientific papers

Stereoselective synthesis of pamamycin-607

A macrodiolide antibiotic pamamycin-607 was synthesized by joining two hydroxy acid components. Three cis-2, 5-disubstituted tetrahydrofuran rings in the molecule were stereoselectively prepared by radical cyclization reactions of β-alkoxyvinyl ketone intermediates and a β-alkoxymethacrylate substrate. The key step of the synthesis is characterized by the predominant threo product formation in the radical cyclization reaction of a β-alkoxymethacrylate intermediate.