482655-63-0

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 329689-23-8 monastrol 
• 141-97-9 ethyl acetoacetate 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 482655-64-1 (R)-3-((2R,3R,4R,5R)-3,4-Bis-benzoyloxy-5-benzoyloxymethyl-tetrahydro-furan-2-carbonyl)-4-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 482655-65-2 (S)-3-((2R,3R,4R,5R)-3,4-Bis-benzoyloxy-5-benzoyloxymethyl-tetrahydro-furan-2-carbonyl)-4-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 254753-54-3 (-)-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester 
• 254753-54-3 (S)-monastrol 

Relevant academic research and scientific papers

Monastrol, a 3,4-dihydropyrimidin-2(1H)-thione, as structural scaffold for the development of modulators for GHB high-affinity binding sites and α1β2δ GABAA receptors

The α4βδ subtype of the γ-aminobutyric acid (GABA) type A receptors (GABAARs) has been shown to be implicated in high-affinity binding of the neuromodulator γ-hydroxybutyric acid (GHB), but may not be the only GHB high-affinity bindi

Improved synthesis and preparative scale resolution of racemic monastrol

The Yb(OTf)3 catalyzed Biginelli cyclocondensation reaction of 3-hydroxybenzaldehyde, ethyl acetoacetate and thiourea afforded the corresponding dihydropyrimidine-2-thione, called monastrol, in 95% isolated yield. The chiral resolution of racem