4828-27-7 Usage
Uses
Used in Pharmaceutical Industry:
Clocortolone is used as a corticosteroid for the treatment of skin inflammation and other skin conditions arising from dermatoses. It helps in reducing inflammation, itching, and redness associated with these conditions, providing relief and promoting healing.
Used in Dermatology:
Clocortolone is used as a topical medication for the treatment of skin inflammation and other skin conditions arising from dermatoses. Its anti-inflammatory and immunosuppressive properties make it an effective treatment option for various skin disorders, such as eczema, psoriasis, and contact dermatitis.
Originator
Clocortolone,Schering AG
Manufacturing Process
6α-Fluoro-16α-methyl-21-hydroxy-1,4,9(11)-pregnatriene-3,20-dione is
suspended in nitroethane at heating. To this suspension 1 N perchloric acid is
added and then t-butyl hypochlorite is added dropwise. The reaction mixture
is agitated at heating, then cooled to room temperature, mixed with
methanol, stirred and then poured with water containing ice. The mixture is
then stirred, thus precipitated product is filtered, washed neutral with water,
dried; The crude product is treated with hot methanol, and recrystallized from
ethanol, thus 9α-chloro-6α-fluoro-11β,21-dihydroxy-16α-methyl-1,4-
pregnadiene-3,20-dione was obtained.
Therapeutic Function
Glucocorticoid
Check Digit Verification of cas no
The CAS Registry Mumber 4828-27-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,2 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4828-27:
(6*4)+(5*8)+(4*2)+(3*8)+(2*2)+(1*7)=107
107 % 10 = 7
So 4828-27-7 is a valid CAS Registry Number.
InChI:InChI=1/C22H28ClFO4/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-21(15,3)22(14,23)18(28)9-20(13,2)19(11)17(27)10-25/h4-5,7,11,13-14,16,18-19,25,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,18+,19-,20+,21+,22+/m1/s1
4828-27-7Relevant academic research and scientific papers
PROCESS FOR THE PREPARATION OF 17-DESOXY-CORTICOSTEROIDS
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Page/Page column 17, (2012/02/05)
The present invention provides an improved process for the preparation of 17-desoxy corticosteroid derivatives in a single chemical step by reacting the 17-hydroxy starting material with an excess of Trimethylsilyl Iodide. The present invention is specifically advantageous in preparing 17-desoxy corticosteroid derivatives having one or more halogen groups at positions 2, 6, 7 or 9 of the corticosteroid such as Clocortolone or Desoximetasone.
Method for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
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, (2008/06/13)
Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.
