4828-34-6

Basic information

• Product Name: 2-CHLOROCYCLOOCTANONE
• Synonyms: 2-chloro-cyclooctanon;2-CHLOROCYCLOOCTANONE;2-Chloro-1-cyclooctanone;2-chlorocyclooctan-1-one
• CAS NO: 4828-34-6
• Molecular Formula: C₈H₁₃ClO
• Molecular Weight: 160.64
• Mol File: 4828-34-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 253.7°Cat760mmHg
• Flash Point: 122.3°C
• Appearance: /
• Density: 1.06g/cm³
• Vapor Pressure: 0.018mmHg at 25°C
• Refractive Index: 1.465
• Storage Temp.: Freezer
• CAS DataBase Reference: 2-CHLOROCYCLOOCTANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROCYCLOOCTANONE(4828-34-6)
• EPA Substance Registry System: 2-CHLOROCYCLOOCTANONE(4828-34-6)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38-43
• Safety Statements: 36/37/39-36/37
• RTECS: GY0175000
• Hazardous Substances Data: 4828-34-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 6707, 1988 DOI: 10.1016/S0040-4039(00)82434-X

InChI:InChI=1/C8H13ClO/c9-7-5-3-1-2-4-6-8(7)10/h7H,1-6H2

Upstream product

• 931-88-4 cis-Cyclooctene 
• 292-64-8 Cyclooctan 
• 104755-28-4 (1-oxo-2-cyclooctanyl)-phenylselenium dichloride 

Downstream Products

• 640733-58-0 C₁₅H₁₈O₂ 
• 640733-58-0 2-phenyl-1-oxaspiro[2.7]decan-4-one 
• 1460-16-8 cycloheptanoic acid 
• 1732-09-8 dimethyl subarate 
• 502-49-8 cycloactanone 
• 14996-79-3 2-phenylcyclooctan-1-one 
• 60433-00-3 methyl cycloheptanecarboxylate 
• 6200-66-4 4,5,6,7,8,9-hexahydro-1H-cyclooctimidazole 

Relevant articles and documents

C-H bond activation by metal oxo species: Chromyl chloride oxidations of cyclooctane, isobutane, and toluene

Chromyl chloride, CrO2Cl2, oxidizes cyclooctane, isobutane, and toluene under mild conditions (25-60 °C). The reactions give chlorinated products (chlorocyclooctane, tert-butyl chloride, and benzyl chloride) and a dark chromium-containing precipitate. Hydrolysis of the precipitate yields oxygenated products, such as ketones, aldehydes, chloro ketones, epoxides, and alcohols. Kinetic data show that all of the reactions are first order in CrO2Cl2 and first order in substrate, with no sign of an induction period. Primary isotope effects have been observed for t-d1-isobutane and d8-toluene. The kinetic and mechanistic data indicate that the reactions proceed by initial hydrogen atom transfer from the substrate to CrO2Cl2 The rates of hydrogen atom abstraction by CrO2Cl2 vary in the order cyclohexane ? and ΔS?, indicating a common mechanism for the four substrates. The pathways leading from the initially formed alkyl radicals to the observed products are described. The ability of CrO2Cl2 to abstract a hydrogen atom from alkanes is remarkable, as it is a closed-shell, diamagnetic species, not a radical. It is proposed that the hydrogen atom abstracting ability derives from the strong O-H bond formed on hydrogen atom transfer, in [Cl2(O)Cr(OH)]. The rates of the CrO2Cl2 reactions correlate with rates of hydrogen atom abstraction by oxygen radicals, assuming a CrO-H bond strength of 83 kcal/mol (similar to that in HMnO4-). The implications of this perspective for transition metal mediated hydrogen atom transfer reactions are discussed.

Metal-Catalyzed Organic Photoreactions. One-Step Synthesis of Chlorinated Ketones from Olefins by Photooxidation in the Presence of Iron(III) Chloride

Under photooxidation in pyridine in the presence of FeCl3, mono- and disubstituted olefins gave α-chloro ketones, while tri- and tetrasubstituted olefins gave dichloro ketones with a C-C bond cleavage.The reaction was interpreted in terms of an electron-transfer mechanism occurring within the coordination sphere of the iron ion