640733-58-0Relevant academic research and scientific papers
Preparation method of alpha, beta-epoxy ketone compound
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Paragraph 0032-0035, (2019/07/29)
The invention provides a method for efficiently preparing an alpha, beta-epoxy ketone compound from alpha-hydrogen-containing alpha-halogenated ketone as a raw material and various aldehydes under theaction of DBU or DBN. Namely the method comprises the steps: slowly and dropwise adding a dichloromethane mixed solution of alpha-halogenated ketone and aldehydes into a dichloromethane solution of DBU or DBN under the conditions of inert gas shielding and 20 DEG C below zero, ending a reaction, and then, carrying out separation and purification to obtain the alpha, beta-epoxy ketone compound. The synthesis method provided by the invention is available in raw material, low in cost, simple and easily-controlled in operation, relatively few in side reactions, simple in aftertreatment, relatively high in product yield, capable of greatly reducing the production cost, relatively high in economic benefit and suitable for large-scale industrial production.
An efficient Darzens reaction promoted by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)
Luo, Juan,Hu, Lanfang,Zhang, Minghao,Tang
supporting information, p. 1949 - 1951 (2019/07/03)
An efficient DBU promoted Darzens reaction utilising α-haloketones containing an enolizable α′-hydrogen is reported. This method diastereoselectively afforded the corresponding α,β-epoxy ketones good to excellent yields in an one-pot reaction without using any transition metals or additives. Furthermore, haloketones without an α′-hydrogen are also applicable in this reaction.
