152460-09-8

Basic information

• Product Name: N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine
• Synonyms: N-(2-METHYL-5-NITROPHENYL)-4-(PYRIDIN-3-YL)PYRIMIDIN-2-AMINE;2-primidinamine,N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl);2-pyrimidinamine,N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl);N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-2-pydimidineamine;(2-methyl-5-nitrophenyl)-(4-(pyridin-3-yl)pyrimidin-2-yl)amine;N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyriMid;2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyriMidin-2-yl]benzenaMine;IMatinib Related CoMpound
• CAS NO: 152460-09-8
• Molecular Formula: C₁₆H₁₃N₅O₂
• Molecular Weight: 307.31
• EINECS: 1806241-263-5
• Product Categories: Imatinib;Aromatics;Bases & Related Reagents;Nucleotides;Intermediate of Imatinib
• Mol File: 152460-09-8.mol
• Article Data: 53

Chemical Properties

• Melting Point: 188-193°C
• Boiling Point: 546.609 °C at 760 mmHg
• Flash Point: 284.379 °C
• Appearance: Yellow/Solid
• Density: 1.344 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.68±0.12(Predicted)
• CAS DataBase Reference: N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine(152460-09-8)
• EPA Substance Registry System: N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine(152460-09-8)

Safety Data

• Hazardous Substances Data: 152460-09-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

N-(2-Methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine (cas# 152460-09-8) is a compound useful in organic synthesis.

Upstream product

• 897031-20-8 4-(pyridin-3-yl)-1,2-dihydropyrimidin-2-one 
• 5089-08-7 (2-methyl-5-nitrophenyl)hydrazine 
• 55314-16-4 3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one 
• 99-99-0 1-methyl-4-nitrobenzene 
• 1692-25-7 3-pyridylboronic acid 
• 99-55-8 2-methyl-5-nitroaniline 
• 55314-16-4 (E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one 
• 637354-25-7 2-(methylsulfonyl)-4-(pyridin-3-yl)pyrimidine 
• 77252-56-3 N-(2-methyl-5-nitrophenyl)formamide 
• 637354-24-6 2-(methylsulfanyl)-4-(3-pyridyl)pyrimidine 
• 152460-08-7 (2-methyl-5-nitrophenyl)guanidine nitrate 
• 152460-07-6 1-(2-methyl-5-nitrophenyl)guanidine 
• 350-03-8 methyl-3-pyridylketone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 152460-10-1 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine 
• 220127-57-1 imatinib mesylate 
• 1346617-86-4 N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-(pyridine-3-yl)pyrimidin-2-amine 
• 1079880-48-0 3-(2-fluoro-ethoxy)-4-methanesulfonyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide 
• 1079880-99-1 C₂₄H₂₁N₅O₄S 
• 1079880-97-9 C₂₃H₁₈IN₅O₂ 
• 1079880-28-6 N-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylphenyl)-3(methylsulfonyl)benzamide 
• 475587-15-6 4-methoxy-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide 
• 1258531-79-1 N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)picolinamide 
• 1202069-89-3 C₂₄H₂₀BrN₅O 

Relevant articles and documents

SUBSTITUTED ARYLUREA COMPOUNDS FOR INDUCING APOPTOSIS AND COMPOSITION FOR ANTICANCER COMPRISING THE SAME

The present invention relates to a substituted arylurea compound inducing apoptosis and an anticancer composition comprising the same. The present invention relates to a novel compound capable of preventing, treating and alleviating cancer diseases such as prostate cancer, breast cancer, lung cancer, colorectal cancer, and skin cancer by inhibiting apoptosis of cancer cells and inhibiting proliferation of cancer cells.

Synthesis method of imatinib and imatinib mesylate

The invention relates to a synthesis method of imatinib and imatinib mesylate. The method comprises the following steps: condensing 3-acetylpyridine and N,N-dimethylformamide dimethyl acetal which aretaken as initial raw materials to obtain 3-dimethylamino-1-(3-pyridyl)-2-propen-1-one, then reacting with 2-methyl-5-nitrophenylguanidine nitrate to form a pyrimidine ring, performing nitro reductionto obtain N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine, amidating the N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine and 4-(chloromethyl)benzoyl chloride, performing affinitysubstitution with 1-methylpiperazine to obtain imatinib, and salifying the imatinib and methanesulfonic acid. The products obtained by the method have the advantages of few impurities, simplicity in post-treatment, high total yield, greenness, environmental protection and safety, and is suitable for a production process for large-scale industrial production of imatinib mesylate.

Imatinib derivative as well as preparation method and application thereof

The invention discloses an imatinib derivative. The chemical name of the imatinib derivative is (E)-1-(3,5-dibromobenzyl)-4-(4-methyl-3-(4-(pyridine-3-yl)pyrimidine-2-amino)phenyl)semicarbazide, and the structural formula of the derivative is shown in the description, wherein R is 3,5-dibromobenzyl. The invention further discloses a preparation method of the imatinib derivative. The preparation ofthe imatinib derivative with a new structure is disclosed and the derivative has certain antitumor activity; the preparation method of the compound is also disclosed, the reaction cost is low, the yield is high, the reaction process is simple and easy to control, and the preparation method is suitable for industrial production.