484-18-4

Basic information

• Product Name: 1-(7-Hydroxy-5-methoxy-2,2-dimethyl-2H-chromen-8-yl)ethanone
• Synonyms: 1-(7-Hydroxy-5-methoxy-2,2-dimethyl-2H-chromen-8-yl)ethanone;1-(7-Hydroxy-5-methoxy-2,2-dimethyl-2H-1-benzopyran-8-yl)ethanone;Alloevodionol
• CAS NO: 484-18-4
• Molecular Formula: C₁₄H₁₆O₄
• Molecular Weight: 248.2744
• Mol File: 484-18-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 71-72 °C
• Boiling Point: 424.7°Cat760mmHg
• Flash Point: 161°C
• Appearance: /
• Density: 1.165g/cm³
• Vapor Pressure: 8.16E-08mmHg at 25°C
• Refractive Index: 1.547
• PKA: 9.55±0.40(Predicted)
• CAS DataBase Reference: 1-(7-Hydroxy-5-methoxy-2,2-dimethyl-2H-chromen-8-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(7-Hydroxy-5-methoxy-2,2-dimethyl-2H-chromen-8-yl)ethanone(484-18-4)
• EPA Substance Registry System: 1-(7-Hydroxy-5-methoxy-2,2-dimethyl-2H-chromen-8-yl)ethanone(484-18-4)

Safety Data

• Hazardous Substances Data: 484-18-4(Hazardous Substances Data)

Usage

General Description

1-(7-Hydroxy-5-methoxy-2,2-dimethyl-2H-chromen-8-yl)ethanone is a chemical compound with a complex structure that contains a chromenyl group and an ethanone group. It is also known as 7-hydroxy-5-methoxy-2,2-dimethyl-2H-chromen-8-yl)ethanone. 1-(7-Hydroxy-5-methoxy-2,2-dimethyl-2H-chromen-8-yl)ethanone is derived from the natural product chromone, and it is found in various plants. It has potential pharmacological properties, with research suggesting it may have antioxidant and anti-inflammatory effects. Additionally, it is being investigated for its potential therapeutic use in treating a variety of health conditions. However, further research is needed to fully understand its mechanisms of action and potential applications.

InChI:InChI=1/C14H16O4/c1-8(15)12-10(16)7-11(17-4)9-5-6-14(2,3)18-13(9)12/h5-7,16H,1-4H3

Upstream product

• 4655-89-4 8-Acetyl-7-hydroxy-5-methoxy-3,4-dihydro-2,2-dimethyl-2H-<1>benzopyran 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 107-86-8 3,3-dimethyl acrylaldehyde 
• 7507-89-3 2,6-dihydroxy-4-methoxy-acetophenone 

Downstream Products

• 1000618-50-7 1-(7-hydroxy-5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-[4-(methoxymethoxy)phenyl]-2-propen-1-one 
• 853926-56-4 C₂₁H₂₀O₄ 
• 52706-65-7 C₂₂H₂₂O₄ 
• 85526-78-9 1-(7-hydroxy-5-methoxy-2,2-dimethyl-chroman-8-yl)-3-phenyl-propan-1-one 
• 4655-89-4 8-Acetyl-7-hydroxy-5-methoxy-3,4-dihydro-2,2-dimethyl-2H-<1>benzopyran 

Relevant articles and documents

DESIGN, SYNTHESIS AND FUNCTIONAL CHARACTERIZATION OF ROTTLERIN ANALOGS

A method of synthesizing rottlerin analogs is described. The synthesis methods described are the first known method of synthesizing rottlerin analogs from commercially-available materials to produce cost effective analogs. Rottlerin analog structures made by the synthesis methods and methods of use for treating a neurological or inflammatory response mediated by protein kinase C (PKC) are further described.

Convenient Synthesis of Alloevodione, Alloevodionol and Franklinone

3,4-Dihydro-6-hydroxy-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (5), obtained by nuclear prenylation of 2,6-dimethoxyquinol, on methylation followed by Friedel-Crafts acetylation gives 8-acetyl-3,4-dihydro-7-hydroxy-5,6-dimethoxy-2,2-dimethyl-2H-1-benzopyran (7).Dehydrogenation of 7 with DDQ followed by methylation affords alloevodione (9).Similar isoprenylation of 2,6-dihydroxy-4-methoxyacetophenone gives a mixture of dichroman (10) and the monochroman (11).Dehydrogenation of 10 and 11 furnishes franklinone (3) and alloevodionol (1) respectively.