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Fumigatin, also known as fumiquinazoline, is a naturally occurring mycotoxin produced by certain fungi, particularly Aspergillus species. It is a potent inhibitor of the enzyme inosine monophosphate dehydrogenase (IMPDH), which plays a crucial role in the synthesis of guanine nucleotides. This inhibition disrupts the replication and transcription processes in cells, leading to cell death. Fumigatin has been studied for its potential antifungal, antiviral, and anticancer properties. It is also used as a pesticide in some countries to control soil-borne pests and diseases in agriculture. However, due to its toxicity, it is important to handle fumigatin with caution and adhere to safety guidelines to prevent adverse health effects.

484-89-9

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484-89-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 484-89-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 4 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 484-89:
(5*4)+(4*8)+(3*4)+(2*8)+(1*9)=89
89 % 10 = 9
So 484-89-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H8O4/c1-4-3-5(9)8(12-2)7(11)6(4)10/h3,11H,1-2H3

484-89-9Relevant academic research and scientific papers

A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice

Yamazaki, Yasuhiro,Yasuda, Kengo,Matsuyama, Tensei,Ishihara, Takuya,Higa, Ryoko,Sawairi, Taira,Yamaguchi, Masahiko,Egi, Masahiro,Akai, Shuji,Miyase, Toshio,Ikari, Akira,Miwa, Masao,Sugatani, Junko

, p. 632 - 644 (2013)

Acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) acetyltransferase is a key enzyme in the biosynthesis of 1-O-alkyl-2-acetyl-sn- glycero-3-phosphocholine (PAF) in inflammatory cells. Sub-stances which inhibit this enzyme are of therapeutic inte

Synthesis and spectroscopic characterization of [1′-14C]ubiquinone-2, [1′-14C]-5-demethoxy-5-hydroxyubiquinone-2, and [1′-14C]-5-demethoxyubiquinone-2

Van Der Klei, Anita,De Jong, Robertus L. P.,Lugtenburg, Johan,Tielens, Aloysius G. M.

, p. 3015 - 3023 (2007/10/03)

[1′-14C]Ubiquinone-2, [1′-14C]-5-demethoxy-5-hydroxyubiquinone-2, and [1′-14C]-5-demethoxyubiquinone-2 have been synthesised from [1-14C]acetic acid. A common feature of these benzoquinones is the isoprenoid chain, and the 14C-label has therefore been incorporated in this isoprenoid. The coupling of the different quinone head groups and the isoprenoid chain is the last step in the total synthesis, to prevent unnecessary loss of the labelled material during synthesis. The products have been characterised by mass spectrometry, 1H NMR and 13C NMR.

Method for dyeing keratinous fibres using a monohydroxyindole or dihydroxyindole and a non-oxidizing aromatic carbonyl derivative and dyeing agent

-

, (2008/06/13)

The present invention relates to a method for dyeing keratinous fibers, characterized in that the following are applied to the fibers: a) a composition (A) containing, in a medium appropriate for dyeing, at least one monohydroxyindole or dihydroxyindole, this application being preceded or followed by the application of b) a composition (B) containing, in a medium appropriate for dyeing, at least one aromatic carbonyl derivative chosen from hydroxyacetophenones, hydroxybenzophenones, 2-hydroxy-1,4-benzoquinones, hydroxy-1,4-naphthoquinones,amino-1,4-naphthoquinones,hydroxy-9,10-anthraquinones and amino-9,10-anthraquinones. It also relates to the dyeing agents for carrying it out.

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