54826-79-8Relevant academic research and scientific papers
A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice
Yamazaki, Yasuhiro,Yasuda, Kengo,Matsuyama, Tensei,Ishihara, Takuya,Higa, Ryoko,Sawairi, Taira,Yamaguchi, Masahiko,Egi, Masahiro,Akai, Shuji,Miyase, Toshio,Ikari, Akira,Miwa, Masao,Sugatani, Junko
, p. 632 - 644 (2013/10/21)
Acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) acetyltransferase is a key enzyme in the biosynthesis of 1-O-alkyl-2-acetyl-sn- glycero-3-phosphocholine (PAF) in inflammatory cells. Sub-stances which inhibit this enzyme are of therapeutic inte
Synthesis and spectroscopic characterization of [1′-14C]ubiquinone-2, [1′-14C]-5-demethoxy-5-hydroxyubiquinone-2, and [1′-14C]-5-demethoxyubiquinone-2
Van Der Klei, Anita,De Jong, Robertus L. P.,Lugtenburg, Johan,Tielens, Aloysius G. M.
, p. 3015 - 3023 (2007/10/03)
[1′-14C]Ubiquinone-2, [1′-14C]-5-demethoxy-5-hydroxyubiquinone-2, and [1′-14C]-5-demethoxyubiquinone-2 have been synthesised from [1-14C]acetic acid. A common feature of these benzoquinones is the isoprenoid chain, and the 14C-label has therefore been incorporated in this isoprenoid. The coupling of the different quinone head groups and the isoprenoid chain is the last step in the total synthesis, to prevent unnecessary loss of the labelled material during synthesis. The products have been characterised by mass spectrometry, 1H NMR and 13C NMR.
