484001-72-1Relevant academic research and scientific papers
Nitroalkenes in the Ni(II) Catalyzed Asymmetric Michael Addition. Convenient Route to the Key Intermediate of Brivaracetam
Reznikov, Alexander N.,Kapranov, Leonid E.,Ivankina, Valentina V.,Sibiryakova, Anastasiya E.,Rybakov, Victor B.,Klimochkin, Yuri N.
, (2018)
A series of Ni(II) complexes with novel chiral ligands derived from (1R,2R)-1,2-diphenylethane-1,2-diamine was synthesized. The catalytic activity of these complexes in the asymmetric Michael reaction is demonstrated. Asymmetric addition of diethyl malonate to ω-nitrostyrene and 1-nitropent-1-ene in the presence of these complexes leads to the enantiomerically enriched diethyl (S)-2-(2-nitro-1-phenylethyl)malonate (up to 96 % ee) and (R)-diethyl 2-(1-nitropenthan-2-yl)malonate (up to 91 % ee). (4R)-4-Propylpyrrolidin-2-one, the key intermediate of antiepileptic drug brivaracetam, was obtained from the corresponding nitroester.
Organocatalytic asymmetric aldol reaction using protonated chiral 1,2-diamines
Shim, Jae Ho,Kim, Min-Joon,Lee, Ji Yeon,Kim, Kyoung Hoon,Ha, Deok-Chan
supporting information, (2020/08/14)
Organic-catalyzed stereoselective reactions have gained attention because they avoid the problems associated with metal catalysts, but existing catalysts based on proline have limitations. Therefore, (R,R)-(+)-1,2-diphenylethylenediamine (DPEN) was select
