484001-72-1

Basic information

• Product Name: (4R,5R)-2,2-dimethyl-4,5-diphenylimidazolidine
• Synonyms: (4R,5R)-2,2-dimethyl-4,5-diphenylimidazolidine
• CAS NO: 484001-72-1
• Molecular Weight: 252.359
• Mol File: 484001-72-1.mol

Chemical Properties

• CAS DataBase Reference: (4R,5R)-2,2-dimethyl-4,5-diphenylimidazolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5R)-2,2-dimethyl-4,5-diphenylimidazolidine(484001-72-1)
• EPA Substance Registry System: (4R,5R)-2,2-dimethyl-4,5-diphenylimidazolidine(484001-72-1)

Safety Data

• Hazardous Substances Data: 484001-72-1(Hazardous Substances Data)

Upstream product

• 35132-20-8 (R,R)-1,2-diphenylethylenediamine 
• 67-64-1 acetone 

Relevant articles and documents

Nitroalkenes in the Ni(II) Catalyzed Asymmetric Michael Addition. Convenient Route to the Key Intermediate of Brivaracetam

A series of Ni(II) complexes with novel chiral ligands derived from (1R,2R)-1,2-diphenylethane-1,2-diamine was synthesized. The catalytic activity of these complexes in the asymmetric Michael reaction is demonstrated. Asymmetric addition of diethyl malonate to ω-nitrostyrene and 1-nitropent-1-ene in the presence of these complexes leads to the enantiomerically enriched diethyl (S)-2-(2-nitro-1-phenylethyl)malonate (up to 96 % ee) and (R)-diethyl 2-(1-nitropenthan-2-yl)malonate (up to 91 % ee). (4R)-4-Propylpyrrolidin-2-one, the key intermediate of antiepileptic drug brivaracetam, was obtained from the corresponding nitroester.

Organocatalytic asymmetric aldol reaction using protonated chiral 1,2-diamines

Organic-catalyzed stereoselective reactions have gained attention because they avoid the problems associated with metal catalysts, but existing catalysts based on proline have limitations. Therefore, (R,R)-(+)-1,2-diphenylethylenediamine (DPEN) was select