484027-06-7Relevant academic research and scientific papers
Free radical-mediated vinyl amination: A mild, general pyrrolidinyl enamine synthesis
Nugent, Benjamin M.,Williams, Amie L.,Prabhakaran,Johnston, Jeffrey N.
, p. 8877 - 8888 (2007/10/03)
The complete scope of free radical-mediated vinyl amination is described, using 5-exo-trig cyclizations of vinyl radicals to the nitrogen of azomethines. The focus is primarily on N,N-dialkyl enamines since their nucleophilicity renders them the most challenging enamines to synthesize using redox conditions. These studies establish several encouraging precedents for the broader application of this strategy.
Free radical-mediated vinyl amination: Access to N,N-dialkyl enamines and their β-stannyl and β-thio derivatives
Prabhakaran, Erode N.,Nugent, Benjamin M.,Williams, Amie L.,Nailor, Kristen E.,Johnston, Jeffrey N.
, p. 4197 - 4200 (2007/10/03)
(Equation presented) The first examples of free radical-mediated vinyl amination are described by nonconventional vinyl radical addition to azomethine nitrogen. This new vinyl amination protocol is mild and provides convenient synthetic access to nonstabi
