484030-89-9

Basic information

• Product Name: 1,4-bis[4-amino-5-mercapto-1,2,4-triazol-3-ylmethoxy]phenylene
• CAS NO: 484030-89-9
• Molecular Weight: 366.428
• Mol File: 484030-89-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,4-bis[4-amino-5-mercapto-1,2,4-triazol-3-ylmethoxy]phenylene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-bis[4-amino-5-mercapto-1,2,4-triazol-3-ylmethoxy]phenylene(484030-89-9)
• EPA Substance Registry System: 1,4-bis[4-amino-5-mercapto-1,2,4-triazol-3-ylmethoxy]phenylene(484030-89-9)

Safety Data

• Hazardous Substances Data: 484030-89-9(Hazardous Substances Data)

Upstream product

• 123-31-9 hydroquinone 
• 2245-53-6 2,2'-[1,4-phenylenebis(oxy)]bisacetic acid 
• 2231-57-4 Thiocarbohydrazide 

Relevant articles and documents

New bis-aminomercaptotriazoles and bis-triazolothiadiazoles as possible anticancer agents

A series of bis-phenoxyacetic acids 2 were prepared starting from corresponding unsubstituted/substituted 1,4-quinols 1. The fusion of bis-phenoxyacetic acids 2 with thiocarbohydrazide gave the corresponding bis-[4-amino-5-mercapto-1,2,4-triazol-3-yl-methyleneoxy]phenylenes (3) in a one pot reaction. The reaction of bis-triazoles 3 with various reagents afforded N-bridged heterocycles 4-6 in good yields. The newly synthesised compounds were screened for their anticancer activity against a panel of 60 cell lines derived from seven cancer types namely, lung, colon, melanoma, renal, ovarian, CNS and leukemia. Some of the tested compounds showed promising anticancer properties.