484052-50-8

Upstream product

• 1824-81-3 2-Amino-6-methylpyridine 
• 484052-47-3 1,3,5-tris(4-benzyloxy-3-methoxycarbonylphenyl)benzene 
• 16475-90-4 estere metilico dell'acido 5-acetilsalicilico 
• 119-36-8 methyl salicylate 
• 484052-48-4 1,3,5-tris(4-benzyloxy-3-carboxyphenyl)benzene 
• 100-39-0 benzyl bromide 
• 117025-64-6 1,3,5-tris(4-hydroxy-3-methoxycarbonylphenyl)benzene 

Relevant academic research and scientific papers

Dual binding mode of methylmethanetriacetic acid to tripodal amidopyridine receptors

A series of tripodal amidopyridine receptors capable of selective recognition of methylmethanetriacetic acid (MMTA) in organic solvents is described. Intramolecular hydrogen-bonding groups, built into some of the receptors, were designed as preorganization devices. Binding was studied by NMR titration, variable temperature NMR experiments, 2D-NMR, isothermal titration calorimetry, and single-crystal X-ray crystallography. The results reveal that a balancing act between inter- and intramolecular hydrogen-bonding interactions in the complexes governs both the dynamics and the geometry of binding. Receptor 1b (without intramolecular hydrogen-bonding groups) features a simple symmetric MMTA binding geometry with optimal enthalpic interactions. In sharp contrast, receptor 1a (with intramolecular hydrogen-bonding groups) reveals a temperature-dependent dual binding mode where MMTA can bind in two completely different geometries. The two solution binding geometries of 1a·MMTA were unraveled by NMR experiments and correlated to the X-ray structures.

Molecular recognition of cis-1,3,5-cyclohexane tricarboxylic acid

The design and synthesis of a new receptor designed to bind tricarboxylic acids in organic solvents is described. The properties of the complex formed between the new receptor and cis-1,3,5-cyclohexanetricarboxylic acid are studied.