4846-84-8

Upstream product

• 901334-68-7 acetic acid phenethylcarbamoyl-methyl ester 
• 79-14-1 glycolic Acid 
• 64-04-0 phenethylamine 
• 623-50-7 ethyl 2-hydroxyacetate 

Downstream Products

• 100391-51-3 methoxycarbonyloxy-acetic acid phenethylamide 
• 224779-60-6 <<oxy>-acetyl>-2-phenylethylamine 
• 948588-63-4 C₂₇H₂₈N₂O₃S 
• 948588-58-7 C₁₇H₁₈N₂OS 
• 2842-37-7 2-(phenethylamino)ethanol 
• 224779-58-2 <<(N-benzyloxycarbonyl-D-phenylalanyl)oxy>-acetyl>-2-phenylethylamine 

Relevant academic research and scientific papers

Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARδ-selective agonists

To find novel PPARδ-selective agonists, we designed and synthesized phenylpropanoic acid derivatives bearing 6-substituted benzothiazoles. Optimization of this series led to the identification of a potent and selective PPARδ agonist 17. Molecular modeling suggested that compound 17 occupies the Y-shaped pocket of PPARδ appropriately.

Novel synthesis of pyridazino[4,5-b][1,4]oxazin-3,8-diones

A novel and effective synthesis of pyridazino[4,5-b][1,4]oxazin-3,8-diones via Smiles rearrangement is presented. Treatment of N-substituted 2-chloro(or hydroxy)acetamide, 2-tetrahydropyranyl-4-chloro-5-hydroxy(or chloro)pyridazin-3-one and cesium carbonate in refluxing acetonitrile was afforded the corresponding pyridazino[4,5-b][1,4]oxazin-3,8-diones in excellent yield.

Comparison of phosphonate transition state analogs for inducing catalytic antibodies and evaluation of key structural factors by an ab initio study

The relation between the structure of haptens and the esterolytic activities of antibodies was investigated. We synthesized two phenylalanine analogs, the negatively charged phosphonate derivative 1 and the neutral phosphonamidate derivative 2. Seventeen out of 41 monoclonal antibodies generated against the hapten 1 hydrolyzed the relevant phenylalanine ester R- 12. On the contrary, none of 27 monoclonal antibodies generated against the hapten 2 had catalytic activity. An ab initio study of the structural and electronic properties of the modeled haptens showed that the value of the negative electrostatic potential around the phosphonyl oxygen was an important factor affecting the induction of esterolytic antibodies.