484657-61-6Relevant academic research and scientific papers
Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor
Song, Eun Young,Kaur, Navneet,Park, Mi-Young,Jin, Yinglan,Lee, Kyeong,Kim, Guncheol,Lee, Ki Youn,Yang, Jee Sun,Shin, Jae Hong,Nam, Ky-Youb,No, Kyoung Tai,Han, Gyoonhee
, p. 1519 - 1524 (2008/09/21)
A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.
Synthesis of N-benzothiazol-2-yl-amides by a copper-catalyzed intramolecular cyclization process
Wang, Junke,Peng, Feng,Jiang, Ju-li,Lu, Zhi-jin,Wang, Le-yong,Bai, Junfeng,Pan, Yi
, p. 467 - 470 (2008/09/17)
Employing N-(4,5-dihydrooxazol-2-yl)benzamide as novel and efficient ligand, the copper-catalyzed intramolecular cyclization of various substituted 1-acyl-3-(2-bromophenyl)thioureas could be successfully carried out under mild conditions. A variety of N-b
