484697-84-9Relevant articles and documents
Identification of a novel 1'-[5-((3,5-dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino)pentyl]-2-oxo-(1,4'-bipiperidine) as a dual NK(1)/NK(2) antagonist.
Ting, Pauline C,Lee, Joe F,Shih, Neng Yang,Piwinski, John J,Anthes, John C,Chapman, Richard W,Rizzo, Charles A,Hey, John A,Ng, Kwokei,Nomeir, Amin A
, p. 2125 - 2128 (2007/10/03)
A novel series of dual NK(1)/NK(2) receptor antagonists, based on the 2-oxo-(1,4'-bipiperidine) template, has been prepared. Compound 10R is a potent dual NK(1)/NK(2) antagonist and demonstrates excellent in vivo activity and good oral plasma levels in the dog.