484697-85-0

Upstream product

• 484697-84-9 3,5-dichloro-N-{2-[1-(3,4-dichloro-phenyl)-3-hydroxy-propyl]-[1,3]dithiolan-2-ylmethyl}-N-methyl-benzamide 
• 2905-62-6 3,5-dichlorobenzoyl chloride 
• 184969-89-9 {2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-yl}-methanol 
• 484697-81-6 2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolane-2-carbaldehyde 
• 484697-82-7 {2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-ylmethyl}-methyl-amine 
• 484697-83-8 N-{2-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dichloro-phenyl)-propyl]-[1,3]dithiolan-2-ylmethyl}-3,5-dichloro-N-methyl-benzamide 

Downstream Products

• 484697-88-3 3,5-dichloro-N-[3-(3,4-dichloro-phenyl)-2-methoxyimino-5-oxo-pentyl]-N-methyl-benzamide 
• 226915-43-1 3,5-dichloro-N-[3-(3,4-dichloro-phenyl)-2-methoxyimino-5-(3-methylcarbamoylmethyl-2-oxo-[1,4']bipiperidinyl-1'-yl)-pentyl]-N-methyl-benzamide 
• 226915-43-1 3,5-dichloro-N-[3-(3,4-dichloro-phenyl)-2-methoxyimino-5-(3-methylcarbamoylmethyl-2-oxo-[1,4']bipiperidinyl-1'-yl)-pentyl]-N-methyl-benzamide 
• 226915-43-1 3,5-dichloro-N-[3-(3,4-dichloro-phenyl)-2-methoxyimino-5-(3-methylcarbamoylmethyl-2-oxo-[1,4']bipiperidinyl-1'-yl)-pentyl]-N-methyl-benzamide 
• 226915-43-1 3,5-dichloro-N-[3-(3,4-dichloro-phenyl)-2-methoxyimino-5-(3-methylcarbamoylmethyl-2-oxo-[1,4']bipiperidinyl-1'-yl)-pentyl]-N-methyl-benzamide 
• 226915-43-1 SCH 206272 

Relevant academic research and scientific papers

Identification of a novel 1'-[5-((3,5-dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino)pentyl]-2-oxo-(1,4'-bipiperidine) as a dual NK(1)/NK(2) antagonist.

A novel series of dual NK(1)/NK(2) receptor antagonists, based on the 2-oxo-(1,4'-bipiperidine) template, has been prepared. Compound 10R is a potent dual NK(1)/NK(2) antagonist and demonstrates excellent in vivo activity and good oral plasma levels in the dog.