4849-88-1

Upstream product

• 17812-38-3 (-)-Nupharamin 
• 140629-59-0 (4R,5R)-4-Methyl-5-(3-methyl-but-2-enyl)-dihydro-furan-2-one 
• 155203-54-6 (4R,5S)-5-azido-4,8-dimethyl-1-(3'-furyl)-6-nonen-1-one 
• 155203-53-5 (4R,5R)-4,8-dimethyl-1-(3'-furyl)-5-hydroxy-6-nonen-1-one 
• 155203-51-3 (3R,4R)-1-[1,3]Dithian-2-ylidene-3,7-dimethyl-oct-6-en-4-ol 
• 155203-52-4 (5R,6R)-6-(3-methyl-2-butenyl)-5-methyl-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 259265-67-3 (4R,5R)-5-(3-methyl-2-butenyl)-4-methyl-2-hydroxytetrahydrofuran 
• 144781-72-6 (1R,2R,3R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(1-chloro-1-methyl-ethyl)-2-methyl-cyclopentanecarboxylic acid methyl ester 
• 144781-81-7 methyl (3S,4R)-4-(tert-butyldimethylsiloxy)-3,7-dimethyl-6-octenoate 

Downstream Products

• 29073-37-8 1-benzoyl-6c-furan-3-yl-3c-methyl-2r-(3-methyl-but-2-enyl)-piperidine 

Relevant academic research and scientific papers

A concise enantiospecific synthesis of nuphar piperidine alkaloids: Total synthesis of (-)-anhydronupharamine, (-)-nupharamine, (-)-nuphenine and (+)-3-epinupharamine

Enantiospecific syntheses of (-)-anhydronupharamine, (-)-nupharamine, (-)-nuphenine, and (+)-3-epinupharamine are achieved starting from (-)- or (+)-carvone as chiral sources, in which a regioselective reductive fragmentation of the cyclopentane derivatives and an intramolecular aza-Wittig reaction were involved as key reactions.

Enantiospecific total syntheses of nuphar piperidine alkaloids, (-)- anhydronupharamine, (-)-nupharamine, (-)-nuphenine and (+)-3-epinupharamine

A concise enantiospecific synthesis of nuphar piperidine alkaloids was achieved by employing a regioselective carbon-carbon bond cleavage reaction of the cyclopentane derivative, having a γ-chloro carbonyl system, as a key reaction.