485318-64-7Relevant academic research and scientific papers
Photo-control of nitric oxide synthase activity using a caged isoform specific inhibitor.
Montgomery, Heather J,Perdicakis, Basil,Fishlock, Dan,Lajoie, Gilles A,Jervis, Eric,Guy Guillemette
, p. 1919 - 1927 (2002)
Nitric oxide (NO) plays a critical role in a number of physiological processes and is produced in mammalian cells by nitric oxide synthase (NOS) isozymes. Because of the diverse functions of NO, pharmaceutical interventions which seek to abrogate adverse
[8-[Bis(carboxymethyl)aminomethyl]-6-bromo-7-hydroxycoumarin-4-yl]methyl Moieties as photoremovable protecting groups for compounds with COOH, NH 2, OH, and C-O functions
Hagen, Volker,Kilic, Funda,Schaal, Janina,Dekowski, Brigitte,Schmidt, Reinhard,Kotzur, Nico
experimental part, p. 2790 - 2797 (2010/08/03)
We introduce a variant of coumarin-based photoactivatable protecting groups and use it exemplarily for caging of a carboxylic acid, an amine, a phenol, and a carbonyl compound. The caged compounds are efficiently photolyzed at long-wavelength UV/vis irradiation. Compared to the corresponding (6-bromo-7-hydroxycoumarin-4-yl)methyl (Bhc) derivatives, the novel coumarin-type caged compounds are distinguished by (i) dramatically increased solubilities in aqueous buffers, (ii) lower pKa values of the C7 hydroxyl of the coumarin chromophore, thus permitting efficient photorelease at lower pH, and (iii) higher photolysis quantum yields in the case of photoprotected carbonyl compounds. The primary step of the photocleavages occurs with rate constants of about 109 s-1.
