485325-14-2Relevant academic research and scientific papers
Novel silyl linkers for solid-phase synthesis
Meloni, Marco M.,Brown,White, Peter D.,Armour, Duncan
, p. 6023 - 6026 (2002)
The syntheses of two silyl chloride resins, 2 and 10 are described starting from Merrifield resin, 3-methyl-1,3-butanediol and diphenyldichlorosilane or dimethyldichlorosilane, respectively. The silyl chloride resin 2 was used for the attachment of 1° alcohols, 2° alcohols and phenols to the solid phase. A preliminary study of the stability of the diphenylsiloxane linker towards certain reaction conditions was also carried out. A more reactive silyl chloride resin 10 was found to be suitable for the attachment of 3° alcohols to the solid phase.
Synthesis and applications of tert-alkoxysiloxane linkers in solid-phase chemistry
Meloni, Marco M.,White, Peter D.,Armour, Duncan,Brown, Richard C.D.
, p. 299 - 311 (2007/10/03)
Straightforward syntheses of two tert-alkoxysilyl chloride functionalised resins 3 and 31 that allow facile attachment of 1°, 2°, 3° alcohols and phenols to the solid-phase have been achieved. Resin 3 displayed useful loading levels (0.7 mmol/g), and it was stable to storage in activated form. Siloxanes from reaction of 3 with alcohols and phenols were compatible with a variety of reaction conditions commonly used in solid-phase synthesis.
