485755-33-7

Basic information

• Product Name: 1-(3-C-allyl-3-O-benzyl-4-hydroxymethyl-β-D-erythro-pentofuranosyl)thymine
• Synonyms: 1-(3-C-allyl-3-O-benzyl-4-hydroxymethyl-β-D-erythro-pentofuranosyl)thymine
• CAS NO: 485755-33-7
• Molecular Weight: 418.447
• Mol File: 485755-33-7.mol

Chemical Properties

• CAS DataBase Reference: 1-(3-C-allyl-3-O-benzyl-4-hydroxymethyl-β-D-erythro-pentofuranosyl)thymine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-C-allyl-3-O-benzyl-4-hydroxymethyl-β-D-erythro-pentofuranosyl)thymine(485755-33-7)
• EPA Substance Registry System: 1-(3-C-allyl-3-O-benzyl-4-hydroxymethyl-β-D-erythro-pentofuranosyl)thymine(485755-33-7)

Safety Data

• Hazardous Substances Data: 485755-33-7(Hazardous Substances Data)

Upstream product

• 485755-31-5 4-C-acetoxymethyl-3-C-allyl-3-O-benzyl-1,2,5-tri-O-acetyl-D-erythro-pentofuranose 
• 457067-99-1 3-C-allyl-3-O-benzyl-4-C-hydroxymethyl-1,2-O-isopropylidene-α-D-erythro-pentofuranose 
• 197702-06-0 3-C-allyl-3-O-benzyl-1,2:5,6-di-O-isopropylidene-α-D-allofuranose 
• 583843-85-0 (R)-1-((3aR,5R,6R,6aR)-6-Allyl-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethane-1,2-diol 
• 175877-45-9 3-C-allyl-1,2:5,6-di-O-isopropylidene-α-D-allofuranose 
• 100-39-0 benzyl bromide 
• 485755-32-6 1-(4-C-acetoxymethyl-3-C-allyl-3-O-benzyl-2,5-di-O-acetyl-β-D-erythro-pentofuranosyl)thymine 

Downstream Products

• 485755-36-0 Toluene-4-sulfonic acid (2S,3S,4R,5R)-3-benzyloxy-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(2-hydroxy-ethyl)-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 485755-35-9 Toluene-4-sulfonic acid (2S,3S,4R,5R)-3-allyl-3-benzyloxy-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 485755-37-1 1-{(2R,3R,3aS,7aR)-3a-Benzyloxy-7a-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-methoxy-hexahydro-furo[2,3-c]pyran-2-yl}-5-methyl-1H-pyrimidine-2,4-dione 
• 774598-74-2 1-(3-C-allyl-3-O-benzyl-4-C-tosyloxymethyl-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl)thymine 
• 774598-78-6 (1R,3R,4R,7S)-1-(4,4'-dimethoxytrityl)oxymethyl-7-hydroxy-7-(2-levulinoyloxyethyl)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 
• 774598-76-4 (1R,3R,4R,7S)-7-benzyloxy-1-(4,4'-dimethoxytrityl)oxymethyl-7-(2-hydroxyethyl)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 
• 774598-75-3 (1R,3R,4R,7S)-7-allyl-7-benzyloxy-1-(4,4'-dimethoxytrityl)oxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 
• 774598-77-5 (1R,3R,4R,7S)-1-(4,4'-dimethoxytrityl)oxymethyl-7-hydroxy-7-(2-hydroxyethyl)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 
• 485755-34-8 1-(3-C-allyl-3-O-benzyl-4-C-tosyloxymethyl-β-D-ribofuranosyl)thymine 

Relevant articles and documents

3′-C-branched LNA-type nucleosides locked in an N-type furanose ring conformation: Synthesis, incorporation into oligocleoxynucleotides, and hybridization studies

Three protected 3′-C-branched LNA-type phosphoramidite building blocks 17, 27, and 38, containing furanose rings locked in an N-type conformation, were synthesized from a known 3-C-allyl allofuranose derivative using strategies relying on the introduction

3′,4′-trans-Linked bicyclic nucleosides locked in S-type conformations

A novel class of 3′,4′-trans-linked bicyclic nucleosides with locked S-type furanose conformations is introduced by synthesis of two model derivatives; one was obtained by cyclic ether formation and the other by ring-closing metathesis methodology.