485801-37-4Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of new-generation taxoids
Ojima, Iwao,Chen, Jin,Sun, Liang,Borella, Christopher P.,Wang, Tao,Miller, Michael L.,Lin, Songnian,Geng, Xudong,Kuznetsova, Larisa,Qu, Chuanxing,Gallager, David,Zhao, Xianrui,Zanardi, Ilaria,Xia, Shujun,Horwitz, Susan B.,Mallen-St. Clair, Jon,Guerriero, Jennifer L.,Bar-Sagi, Dafna,Veith, Jean M.,Pera, Paula,Bernacki, Ralph J.
experimental part, p. 3203 - 3221 (2009/05/11)
Novel second-generation taxoids with systematic modifications at the C2, C10, and C3′N positions were synthesized and their structure-activity relationships studied. A number of these taxoids exhibited exceptionally high potency against multidrug-resistan
Cytotoxic agents containing novel potent taxanes and their therapeutic use
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Page/Page column 10, Sheet 8, (2008/06/13)
Included within the scope of the present invention are potent taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in select
Tumor-specific novel taxoid-monoclonal antibody conjugates
Ojima, Iwao,Geng, Xudong,Wu, Xinyuan,Qu, Chuanxing,Borella, Christopher P.,Xie, Hongsheng,Wilhelm, Sharon D.,Leece, Barbara A.,Bartle, Laura M.,Goldmacher, Victor S.,Chari, Ravi V. J.
, p. 5620 - 5623 (2007/10/03)
Taxoids bearing methyldisulfanyl(alkanoyl) groups for taxoid-antibody immunoconjugates were designed, synthesized and their activities evaluated. A highly cytotoxic C-10 methyldisulfanylpropanoyl taxoid was conjugated to monoclonal antibodies recognizing
