653587-20-3Relevant academic research and scientific papers
Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies
Miller, Michael L.,Roller, Elizabeth E.,Wu, Xinyaun,Leece, Barbara A.,Goldmacher, Victor S.,Chari, Ravi V.J.,Ojima, Iwao
, p. 4079 - 4082 (2007/10/03)
The targeted delivery of taxoids, in the form of taxane-antibody immunoconjugates, requires the preparation of taxoids containing moieties suitable for their conjugation to monoclonal antibodies. A series of taxoids incorporating a disulfide-containing li
Cytotoxic agents containing novel potent taxanes and their therapeutic use
-
Page/Page column 10, Sheet 8, (2008/06/13)
Included within the scope of the present invention are potent taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in select
