485828-75-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(6-Chloropyridin-3-yl)cyclobutanecarbonitrile is utilized as a key intermediate in the synthesis of various drug molecules, leveraging its ability to engage in a range of chemical reactions. Its presence in the structure of synthesized compounds can contribute to the development of new pharmaceuticals with distinct therapeutic profiles.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(6-Chloropyridin-3-yl)cyclobutanecarbonitrile is employed as a valuable tool for the design and creation of novel compounds with potential biological activity. The chloropyridine group in its structure allows for the exploration of new chemical space and the enhancement of drug-like properties in the molecules being developed.
Overall, 1-(6-Chloropyridin-3-yl)cyclobutanecarbonitrile plays a significant role in drug discovery and development, serving as a crucial component in the advancement of pharmaceutical research and the creation of innovative therapeutic agents.

Upstream product

• 39891-09-3 (6-chloro-pyridin-3-yl)-acetonitrile 
• 109-64-8 1,3-dibromo-propane 
• 106-93-4 ethylene dibromide 
• 68-12-2 N,N-dimethyl-formamide 

Relevant academic research and scientific papers

NOVEL SALTS OF INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS

Provided herein are compounds, salts, crystalline forms, and pharmaceutical compositions that are related to IDO inhibitors, in particular, Compound 1,1-(5-((4-chlorophenyl)amino)-6-(ethyl(tetrahydro-2H-pyran-4-yl)amino)pyridin-3-yl)cyclobutane-1-carboxylic acid. Also provided are methods of treating a disease or disorder such as a cancer or infectious disease that comprises administering to a subject in need thereof one or more of the compounds or compositions of the present disclosure.

NOVEL BICYCLIC HETEROCYCLIC COMPOUND

Provided are a novel compound having a superior inhibitory action on KAT-II, a production method thereof, use thereof, and a pharmaceutical composition containing the aforementioned compound and the like. A compound represented by the formula (I) or a pharmacologically acceptable salt thereof. wherein each symbol is as defined in the DESCRIPTION.

INHIBITOR OF INDOLEAMINE-2,3-DIOXYGENASE (IDO)

The present disclosure provides compounds of Formula (I). The compounds described herein may be useful in treating a disease associated with IDO, for example, cancer or an infectious disease (e.g., viral or bacterial infectious diseases). Also, provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION

The present invention relates to compounds of formula (I) and (IA) and pharmaceutically acceptable salts thereof, wherein R1- R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.