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4863-70-1

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4863-70-1 Usage

General Description

4-(4-chlorophenyl)-3-phenylbutan-2-one, also known as 4-CPP, is a chemical compound with the molecular formula C16H15ClO. It is a yellowish crystalline solid with a slightly sweet odor, and it is commonly used in the synthesis of pharmaceuticals and other organic compounds. 4-CPP is a ketone compound with a chlorophenyl and phenyl group attached to the carbon chain, and it has been found to have various biological activities, making it a valuable intermediate in the development of therapeutic agents. 4-(4-chlorophenyl)-3-phenylbutan-2-one is also known to exhibit moderate toxicity and should be handled with appropriate safety precautions. Overall, 4-(4-chlorophenyl)-3-phenylbutan-2-one is an important chemical in the field of organic synthesis and pharmaceutical research.

Check Digit Verification of cas no

The CAS Registry Mumber 4863-70-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,6 and 3 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4863-70:
(6*4)+(5*8)+(4*6)+(3*3)+(2*7)+(1*0)=111
111 % 10 = 1
So 4863-70-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H15ClO/c1-12(18)16(14-5-3-2-4-6-14)11-13-7-9-15(17)10-8-13/h2-10,16H,11H2,1H3

4863-70-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(4-chlorophenyl)-3-phenylbutan-2-one

1.2 Other means of identification

Product number -
Other names 4-(4-chlorophenyl)-3-phenyl-2-butanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4863-70-1 SDS

4863-70-1Relevant articles and documents

Synthesis of β-Amino Diaryldienones Using the Mannich Reaction

Elshan, N. G. R. Dayan,Rettig, Matthew B.,Jung, Michael E.

, (2019/06/13)

The Mannich reaction has been used for decades to prepare many pharmaceutically important molecules. Here, using a "double-Mannich-β-elimination" synthetic sequence, we report the synthesis and the characterization details of a novel class of β-amino diaryldienones with prominent antiprostate cancer activity. Through these studies, we correct an erroneous structure in the current literature, present a discussion of the stereochemical outcome of a new reaction, and probe the mechanism(s) of byproduct formation through isotopic studies.

Discovery of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1- methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity

Lin, Linus S.,Lanza Jr., Thomas J.,Jewell, James P.,Liu, Fing,Shah, Shrenik K.,Qi, Hongbo,Tong, Xinchun,Wang, Junying,Xu, Suoyu S.,Fong, Tung M.,Shen, Chun-Pyn,Lao, Julie,Xiao, Jing Chen,Shearman, Lauren P.,Stribling, D. Sloan,Rosko, Kimberly,Strack, Alison,Marsh, Donald J.,Feng, Yue,Kumar, Sanjeev,Samuel, Koppara,Yin, Wenji,Van Der Ploeg, Lex H. T.,Goulet, Mark T.,Hagmann, William K.

, p. 7584 - 7587 (2007/10/03)

The discovery of novel acyclic amide cannabinoid-1 receptor inverse agonists is described. They are potent, selective, orally bioavailable, and active in rodent models of food intake and body weight reduction. A major focus of the optimization process was to increase in vivo efficacy and to reduce the potential for formation of reactive metabolites. These efforts led to the identification of compound 48 for development as a clinical candidate for the treatment of obesity.

ARALKYL AMINES AS CANNABINOID RECEPTOR MODULATORS

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Page/Page column 45, (2010/02/11)

Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson’s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, including alcohol and nicotine addiction, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.

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