4864-39-5

Usage

Uses

Used in Pharmaceutical Industry:
L-Leucine, N-[(phenylmethoxy)carbonyl]-L-alanyl-, methyl ester is used as a building block for the synthesis of peptides, which are essential in the development of pharmaceuticals. Peptides are short chains of amino acids that can be used as therapeutic agents, and Boc-L-Leucine plays a significant role in their production.
Used in Biochemical Research:
In the field of biochemical research, L-Leucine, N-[(phenylmethoxy)carbonyl]-L-alanyl-, methyl ester is used as a component in the synthesis of peptides for studying their structure, function, and interactions with other biomolecules. This helps researchers gain insights into various biological processes and develop new therapeutic strategies.
It is important to handle and store Boc-L-Leucine according to proper safety protocols due to its potential hazards and risks.

Upstream product

• 2666-93-5 (S)-Leu-OMe 
• 1142-20-7 N-Cbz-Ala 
• 1168-87-2 benzyloxycarbonylalanine p-nitrophenyl ester 
• 52435-10-6 Z-Ala-ONB 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 24959-68-0 N-Cbz-L-Ala-L-Leu 
• 77-76-9 2,2-dimethoxy-propane 
• 67-56-1 methanol 
• 27167-65-3 (S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)propanamido)-4-methylpentanoate 
• 24692-86-2 N-Cbz-L-alanine p-toluene thiol ester 
• 4132-86-9 N-benzyloxycarbonylalanine 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 501-53-1 benzyl chloroformate 
• 61-90-5 L-leucine 

Downstream Products

• 3038-22-0 Z-Ala-Leu-OEt 
• 610784-46-8 Oc-Aib-Pro-Phe-Aib-Glu(OMe)-Glu(OMe)-Aib-Etn-Glu(OMe)-Ala-Lol 
• 610784-47-9 Oc-Aib-Pro-Phe-Aib-Glu(OMe)-Glu(OMe)-Aib-Nva-Glu(OMe)-Ala-Lol 
• 610784-45-7 Oc-Aib-Pro-Phe-Aib-Glu(OMe)-Glu(OMe)-Aib-Aib-Glu(OMe)-Ala-Lol 
• 610784-35-5 Z-Aib-Etn-Glu(OMe)-Ala-Lol 
• 610784-36-6 Z-Aib-Nva-Glu(OMe)-Ala-Lol 
• 610784-34-4 Z-Aib-Aib-Glu(OMe)-Ala-Lol 
• 610784-32-2 Z-Etn-Glu(OMe)-Ala-Lol 
• 610784-33-3 Z-Nva-Glu(OMe)-Ala-Lol 
• 610784-31-1 Z-Aib-Glu(OMe)-Ala-Lol 
• 1803-60-7 (3S,6S)-3-methyl-6-(2-methylpropyl)piperazine-2,5-dione 
• 177657-03-3 Z-Ala-Lol 
• 136497-30-8 Z-Ala-Leu-OCHMe₂ 
• 80165-15-7 {(S)-1-[(S)-1-((S)-1-Carbamoyl-3-methyl-butylcarbamoyl)-3-methyl-butylcarbamoyl]-ethyl}-carbamic acid benzyl ester 

Relevant academic research and scientific papers

N-Triazinylammonium salts, a method of preparation and uses thereof

The invention provides inner quaternary N-triazinyl- ammonium salts of sulphonic acids, of the Formula 1, a method of preparation thereof and a use thereof as condensation reagents in condensation reactions.

Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters

Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters in the presence of bis(trimethylsilyl) acetamide (BSA) has been developed. This general method provides convenient access to N-protected peptides in good yields under mild condi

Fully enzymatic peptide synthesis using C-terminal tert-butyl ester interconversion

Chemoenzymatic peptide synthesis is potentially the most cost-efficient technology for the synthesis of short and medium-sized peptides with some important advantages. For instance, stoichiometric amounts of expensive coupling reagents are not required an

Design, synthesis, and application of enantioselective coupling reagent with a traceless chiral auxiliary

(Chemical Equation Presented) Stable chiral N-triazinylbrucinium tetrafluoroborate enantioselectively activates racemic carboxylic acids yielding enantiomerically enriched amides, esters, and dipeptides with er from 8:92 to 0.5:99.5. Due to the departure

Structures, sensory activity, and dose/response functions of 2,5-diketopiperazines in roasted cocoa nibs (Theobroma cacao)

The taste compounds inducing the blood-like, metallic bitter taste sensation reported recently for a dichloromethane extract prepared from roasted cocoa nibs were identified as a series of 25 diketopiperazines by means of HPLC degustation, LC-MS/MS, and i

Bromelain catalyzed synthesis of peptides in organic solvent

For the first time, immobilized bromelain was shown to maintain high catalytic activity in organic solvent and to form peptide bonds. It requires only 7 hours to obtain Cbz-Gly-L-Leu-OMe in 85% yield. The precursor of aspartame (Cbz-L-Asp-L-Phe-OMe) and other dipeptides were also synthesized by this method.

Lipopeptaibol metabolites of tolypocladium geodes: Total synthesis, preferred conformation, and membrane activity

We have synthesized by solution methods and characterized the lipopeptaibol metabolite LP237-F8 extracted from the fungus Tolypocladium geodes and five selected analogues with the Etn → Aib or Etn → Nva replacement at position 8 and/or a triple Gln → Glu(OMe) replacement at positions 5, 6, and 9 (Etn = Cα-ethylnorvaline, Aib = α-aminoisobutyric acid, Nva = norvaline). Conformation analysis, performed by FT-IR absorption, NMR, and CD techniques, strongly supports the view that the six terminally blocked decapeptides are highly helical in solution. Helix topology and amphiphilic character are responsible for their remarkable membrane activity. At position 8 the combination of high hydrophobicity and Ca tetrasubstitution, as in the Etn-containing LP237-F8 metabolite, has a positive effect on membrane interaction.

Tandem deprotection-coupling of N(α)-Alloc-amino acids by use of ternary systems Pd cat./PhSiH3/carboxy-activated amino acid

N(α)-allyloxycarbonyl derivatives of amino acids undergo smooth coupling with various carboxy-activated partners when treated with phenylsilane (PhSiH3) in the presence of catalytic amounts of tetrakis- (triphenylphosphine) palladium.

Comparative study of selected coupling reagents in dipeptide synthesis

A comparative study of the effectiveness of selected coupling reagents in dipeptide synthesis was conducted. Included in the study were a new coupling agent, pentafluorophenyl diphenylphosphinate (FDPP, 1), benzotriazol-1-yl-oxytris(dimethylamino)phosphon