486403-42-3

Upstream product

• 541-57-1 4-hydroxy-2(5H)-furanone 
• 95-54-5 1,2-diamino-benzene 
• 4971-56-6 tetrahydrofuran-2,4-dione 

Downstream Products

• 1100269-64-4 10-phenethyl-3,4,9,10-tetrahydro-1H-furo[3,4-b][1,5]benzodiazepin-1-one 
• 1100269-63-3 10-(3,4-dimethoxyphenyl)-3,4,9,10-tetrahydro-1H-benzo[b]furo[3,4-e][1,4]diazepin-1-one 
• 1313371-27-5 10-phenyl-3,4,9,10-tetrahydro-1H-benzo[b]furo[3,4-e][1,4]diazepin-1-one 
• 1313371-30-0 10-(3,4,5-trimethoxyphenyl)-3,4,9,10-tetrahydro-1H-benzo[b]furo[3,4-e][1,4]diazepin-1-one 
• 1313371-28-6 10-(p-tolyl)-3,4,9,10-tetrahydro-1H-benzo[b]furo[3,4-e][1,4]diazepin-1-one 

Relevant academic research and scientific papers

Synthesis and biological evaluation of benzo[b]furo[3,4-e][1,4]diazepin-1-one derivatives as anti-cancer agents

A new series of novel Podophyllotoxin-like benzo[b]furo[3,4-e][1,4]diazepin-1-ones possessing structural elements of 4-aza-2,3-didehydropodophyllotoxins with central diazepine ring was designed and synthesized as anti-cancer agents. In initial assessment,

Electroactive 1,5-benzodiazepines bearing either a tetrathiafulvalene or a ferrocene moiety

The synthesis of a series of electroactive 1,5-benzodiazepines bearing either a ferrocene or tetrathiafulvalene core, acting as the electroactive moiety, is reported. The electron donating ability of these redox active 1,5-benzodiazepines is described tog

Efficient synthesis of functionalized benzimidazoles and perimidines: Ytterbium chloride catalyzed C-C bond cleavage

An efficient method is developed for the synthesis of functionalized benzimidazoles and perimidines by the condensation of aryl diamines with β-carbonyl compounds catalyzed by ytterbium chloride. The reactions give good yields under mild conditions. A mechanism involving a lanthanide activated C-C bond cleavage is proposed. An efficient method is developed for the synthesis of functionalized benzimidazoles and perimidines by the condensation of aryl diamines with β-carbonyl compounds catalyzed by ytterbium chloride. The reactions give good yields under mild conditions. A mechanism involving a lanthanide activated C-C bond cleavage is proposed. Copyright

[4+2+1] domino cyclization in water for chemo- and regioselective synthesis of spiro-substituted benzo[b]furo[3,4-e][1,4]diazepine derivatives

New regio- and chemoselective [4+2+1] domino cyclization consisting of the formation of two spiro rings and five σ bonds has been developed for the synthesis of spiro-substituted benzo[b]furo[3,4-e][1,4]diazepine derivatives. The reaction is a multicompon

Synthesis of tetracyclic pyrano[4,3-b]-6H-imidazo[1,2-a] [1,5]benzodiazepines

A synthetic route to tetracyclic pyrano[4,3-b]-imidazo[1,2-a][1,5] benzodiazepines is described. The key is the intramolecular cyclization using cyanogen bromide of enaminones, obtained from reaction of pyrone or tetronic acid with o-phenylenediamine deri

Reactivity studies on 4-aminopyrones: Access to benzimidazole and benzimidazolone derivatives

Reaction of pyrone 1a or tetronic acid 1b with o-phenylenediamine derivatives gave enaminone compounds 2. When reacting with different electrophiles, these intermediates allowed versatile access to different heterocyclic structures: when DMA derivatives o