486422-05-3

Usage

Uses

Used in Pharmaceutical Synthesis:
3-(N,N-Dimethylaminosulfonyl)phenylboronic acid pinacol ester is used as a key intermediate in the synthesis of pharmaceuticals for its ability to facilitate the formation of complex organic molecules. Its reactivity allows for the creation of a wide array of drug candidates with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 3-(N,N-Dimethylaminosulfonyl)phenylboronic acid pinacol ester is utilized as a building block in the development of new pesticides and other agrochemicals. Its versatility in organic synthesis contributes to the design of novel compounds with improved efficacy and selectivity in crop protection.
Used in the Development of New Materials:
3-(N,N-Dimethylaminosulfonyl)phenylboronic acid pinacol ester is employed as a precursor in the synthesis of new materials with unique properties. Its incorporation into these materials can lead to advancements in areas such as polymer science, materials engineering, and nanotechnology.
Used as a Catalyst in Chemical Reactions:
3-(N,N-Dimethylaminosulfonyl)phenylboronic acid pinacol ester is used as a catalyst to enhance the efficiency of various chemical reactions. Its ability to participate in multiple types of reactions allows it to accelerate processes and improve the overall yield of desired products in the synthesis of fine chemicals and other organic compounds.

Upstream product

• 14417-01-7 N,N-dimethylbenzenesulfonamide 
• 73183-34-3 bis(pinacol)diborane 
• 153435-80-4 3-bromo-N,N-dimethyl-benzenesulfonamide 
• 2905-24-0 3-Bromobenzenesulfonyl chloride 

Downstream Products

• 1152473-60-3 N,N-dimethyl-3-(2-(4-morpholinophenylamino)thieno[3,2-d]pyrimidin-7-yl)benzenesulfonamide 

Relevant academic research and scientific papers

Meta Selective C-H Borylation of Sterically Biased and Unbiased Substrates Directed by Electrostatic Interaction

An electrostatically directed meta borylation of sterically biased and unbiased substrates is described. The borylation follows an electrostatic interaction between the partially positive and negative charges between the ligand and substrate. With this strategy, it has been demonstrated that a wide number of challenging substrates, especially 4-substituted substrates, can selectively be borylated at the meta position. Moreover, unsubstituted substrates also displayed excellent meta selectivity. The reaction employs a bench-stable ligand and proceeds at a milder temperature, precluding the need to synthesize a bulky and sophisticated ligand/template.

Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics**

Protein arginine N-methyl transferase 4 (PRMT4) asymmetrically dimethylates the arginine residues of histone H3 and nonhistone proteins. The overexpression of PRMT4 in several cancers has stimulated interest in the discovery of inhibitors as biological tools and, potentially, therapeutics. Although several PRMT4 inhibitors have been reported, most display poor selectivity against other members of the PRMT family of methyl transferases. Herein, we report the structure-based design of a new class of alanine-containing 3-arylindoles as potent and selective PRMT4 inhibitors, and describe key structure–activity relationships for this class of compounds.

HSD17B13 INHIBITORS AND USES THEREOF

Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH,