486453-65-0 Usage
Uses
Used in Pharmaceutical Research:
NTNCB Hydrochloride is used as a research compound for studying the interaction with DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5). This application is significant for understanding the receptor's role in various physiological processes and potentially developing targeted therapies for related conditions.
Used in Chemical Synthesis:
As a complex organic molecule, NTNCB Hydrochloride may also be used as a starting material or intermediate in the synthesis of other compounds with potential applications in various industries, such as pharmaceuticals, agrochemicals, or materials science.
Biological Activity
Selective, non-peptide competitive NPY Y 5 antagonist. K i values are 8.0 and 16032 nM at human recombinant Y 5 and Y 1 receptors respectively. Potently antagonizes NPY inhibition of forskolin-stimulated cAMP. Displays some affinity for cloned human D 2 and α 2C receptors (K i values are 63 and 100 nM respectively).
Check Digit Verification of cas no
The CAS Registry Mumber 486453-65-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,8,6,4,5 and 3 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 486453-65:
(8*4)+(7*8)+(6*6)+(5*4)+(4*5)+(3*3)+(2*6)+(1*5)=190
190 % 10 = 0
So 486453-65-0 is a valid CAS Registry Number.
InChI:InChI=1/C25H33N3O4S.ClH/c29-28(30)24-7-3-4-8-25(24)33(31,32)27-18-20-11-9-19(10-12-20)16-26-17-21-13-14-22-5-1-2-6-23(22)15-21;/h1-8,19-21,26-27H,9-18H2;1H/t19-,20-,21?;
486453-65-0Relevant academic research and scientific papers
Islam, Imadul,Dhanoa, Dale,Finn, John,Du, Ping,Walker, Mary W,Salon, John A,Zhang, Jack,Gluchowski, Charles
, p. 1767 - 1769 (2002)
The discovery of a new class of sulfonamide NPY Y5 receptor antagonists is described. Optimization of this series led to the identification of compounds with high affinity for the hY5 subtype and excellent selectivity over the other NPY receptor subtypes. The SAR for this series was examined and a model for understanding the ligand-receptor interactions was developed.
