486460-26-8

Basic information

• Product Name: (4-bromo-2,5-difluorophenyl)methanol
• Synonyms: (4-bromo-2,5-difluorophenyl)methanol;BenzeneMethanol, 4-broMo-2,5-difluoro-;4-Bromo-2,5-difluorobenzyl alcohol
• CAS NO: 486460-26-8
• Molecular Formula: C₇H₅BrF₂O
• Molecular Weight: 223
• Mol File: 486460-26-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 254.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.744±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.22±0.10(Predicted)
• CAS DataBase Reference: (4-bromo-2,5-difluorophenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (4-bromo-2,5-difluorophenyl)methanol(486460-26-8)
• EPA Substance Registry System: (4-bromo-2,5-difluorophenyl)methanol(486460-26-8)

Safety Data

• Hazardous Substances Data: 486460-26-8(Hazardous Substances Data)

Usage

General Description

(4-bromo-2,5-difluorophenyl)methanol is a chemical compound with the formula C7H5BrF2O. It is a white solid with a molecular weight of 221.013 g/mol. (4-bromo-2,5-difluorophenyl)methanol is used in various chemical reactions and processes, including in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block for the production of other organic compounds. Its structure contains a phenyl ring with bromine and fluorine substituents, as well as a hydroxyl group attached to a methylene (CH2) group. The presence of both electron-withdrawing and electron-donating groups makes this compound a versatile intermediate in organic synthesis.

Upstream product

• 357405-75-5 4-bromo-2,5-difluorobenzaldehyde 
• 28314-82-1 4-bromo-2,5-difluorobenzoic acid 
• 327-51-5 1,4-dibromo-2,5-difluorobenzene 

Downstream Products

• 1620076-13-2 C₁₃H₇BrF₂N₂O 
• 1341660-62-5 1-bromo-4-(chloromethyl)-2,5-difluoro-benzene 
• 486460-10-0 1-bromo-4-(bromomethyl)-2,5-difluorobenzene 

Relevant articles and documents

1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors

N6-methyladenosine (m6A) is the most frequent of the 160 RNA modifications reported so far. Accumulating evidence suggests that the METTL3/METTL14 protein complex, part of the m6A regulation machinery, is a key player in a variety of diseases including several types of cancer, type 2 diabetes, and viral infections. Here we report on a protein crystallography-based medicinal chemistry optimization of a METTL3 hit compound that has resulted in a 1400-fold potency improvement (IC50 of 5 nM for the lead compound 22 (UZH2) in a time-resolved F?rster resonance energy transfer (TR-FRET) assay). The series has favorable ADME properties as physicochemical characteristics were taken into account during hit optimization. UZH2 shows target engagement in cells and is able to reduce the m6A/A level of polyadenylated RNA in MOLM-13 (acute myeloid leukemia) and PC-3 (prostate cancer) cell lines.

ALDH2 ACTIVATOR

The present invention provides a compound represented by formula (1): or pharmaceutically acceptable salt thereof, wherein X and Y are the same or different from each other and represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group, wherein the C1-6 alkoxy group may be substituted with a C1-6 alkoxy group, andZ and W are the same or different from each other and represent a hydrogen atom, a halogen atom, or a C1-6 alkyl group.

BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.