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4866-61-9

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4866-61-9 Usage

General Description

[1,2,4]triazolo[1,5-a]pyrimidin-7(1H)-one is an organic compound with the molecular formula C6H5N5O. It belongs to the class of pyrimidine derivatives and contains a triazolopyrimidine core structure. The compound is known for its potential pharmacological activities and is used as a building block in the synthesis of various pharmaceuticals. It exhibits antitumor, antiviral, and antimicrobial properties, making it a valuable target for drug development. Additionally, it has been studied for its potential use in the treatment of neurological disorders and as an analgesic agent. Overall, [1,2,4]triazolo[1,5-a]pyrimidin-7(1H)-one is a versatile chemical with the potential for various medical and pharmaceutical applications.

Check Digit Verification of cas no

The CAS Registry Mumber 4866-61-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,6 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4866-61:
(6*4)+(5*8)+(4*6)+(3*6)+(2*6)+(1*1)=119
119 % 10 = 9
So 4866-61-9 is a valid CAS Registry Number.

4866-61-9Relevant articles and documents

Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates

Heinrich, Timo,Buchstaller, Hans-Peter,Cezanne, Bertram,Rohdich, Felix,Bomke, J?rg,Friese-Hamim, Manja,Krier, Mireille,Kn?chel, Thorsten,Musil, Djordje,Leuthner, Birgitta,Zenke, Frank

, p. 551 - 556 (2017/01/17)

The natural product fumagillin 1 and derivatives like TNP-470 2 or beloranib 3 bind to methionine aminopeptidase 2 (MetAP-2) irreversibly. This enzyme is critical for protein maturation and plays a key role in angiogenesis. In this paper we describe the synthesis, MetAP-2 binding affinity and structural analysis of reversible MetAP-2 inhibitors. Optimization of enzymatic activity of screening hit 10 (IC50: 1?μM) led to the most potent compound 27 (IC50: 0.038?μM), with a concomitant improvement in LLE from 2.1 to 4.2. Structural analysis of these MetAP-2 inhibitors revealed an unprecedented conformation of the His339 side-chain imidazole ring being co-planar sandwiched between the imidazole of His331 and the aryl-ether moiety, which is bound to the purine scaffold. Systematic alteration and reduction of H-bonding capability of this metal binding moiety induced an unexpected 180° flip for the triazolo[1,5-a]pyrimdine bicyclic template.

NOVEL HETEROCYCLIC COMPOUNDS AS METAP-2 INHIBITORS

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Page/Page column 16-17, (2011/11/30)

Compounds of the formula I, in which D, X, Y, Z, R and R1 have the meanings indicated in Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.

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