4870-90-0Relevant academic research and scientific papers
Practical, environment-benign and atom economic KOAc-catalysed deprotection of aryl TIPS ethers under mild fluoride-free conditions
Wang, Bing,Sun, Hui-Xia,Chen, Bo,Sun, Zhi-Hua
supporting information; experimental part, p. 1112 - 1114 (2010/04/23)
A KOAc-catalysed, fluoride-free protocol not only effects chemoselective deprotection of phenolic TIPS ethers without affecting acetal, ketal, carbamate, O-acetyl and aliphatic silyl ethers, but also improves its atom economy by recycling the silanol byproduct.
Synthesis and bovine β3-adrenergic agonistic activities of a novel series of aryloxypropanolamines
El Hadri,Nicolle,Guillaume,Leclerc,Pietri-Rouxel,Strosberg,Archimbault
, p. 517 - 522 (2007/10/03)
We synthesized a novel series of 21 aryloxypropanolamine compounds characterized by N-alkyl, aralkyl, and aryl substituents. The compounds showed potent β3-adrenergic agonistic activities in Chinese hamster ovary cells expressing the bovine β3-adrenoceptors with Kact and Ki values of 4.2 ± 3.0 nM and 459 ± 169 nM respectively, for the ligand with the best compromise between potency and affinity. Structure-activity relationships are discussed.
