4877-10-5Relevant academic research and scientific papers
Synthesis and Structures of [2.n]Metacyclophan-1-enes and their Conversion to Highly Strained [2.n]Metacyclophane-1-ynes
Akther, Thamina,Islam, Md. Monarul,Kowser, Zannatul,Matsumoto, Taisuke,Tanaka, Junji,Rahman, Shofiur,Alodhayb, Abdullah,Georghiou, Paris E.,Redshaw, Carl,Yamato, Takehiko
, p. 4167 - 4175 (2020/07/13)
The syntheses of syn-[2.n]metacyclophan-1-enes (n = 5, 6, 8) in good yields using the McMurry cyclization of 1,n-bis(3-formyl-4-methoxyphenyl)alkanes are reported. Conversion of syn-[2.6]- and [2.8]metacyclophan-1-enes to the corresponding highly strained syn-type [2.6]- and [2.8]metacyclophane-1-ynes was achieved by successive bromination and dehydrobromination reactions. An attempted trapping reaction of the putative corresponding [2.5]metacyclophane-1-yne by Diels–Alder reaction with 1,3-diphenylisobenzofuran failed due to its smaller ring size and strained structure. X-ray crystallographic analyses show that the triple bonds in syn-[2.6]- and [2.8]metacyclophane-1-ynes are distorted from linearity with bond angles of 156.7° and 161.4°, respectively. A DFT (Density Functional Theory) computational study was conducted to determine the stabilities of different conformations of the target compounds.
Iridium-catalyzed reactions of ω-Arylalkanols to α,ω- Diarylalkanes
Obora, Yasushi,Anno, Yuka,Okamoto, Ryuhei,Matsu-Ura, Toyomi,Ishii, Yasutaka
, p. 8618 - 8622 (2011/11/11)
The long and the short of it: An atom-economical route to α,ω-diarylalkanes from ω-arylalkanols was achieved by a direct one-step method, or a sequential two-step method depending on the alkyl chain length. The reaction proceeded through the formation of β-methylhydroxy- α,ω-diarylalkanes by dehydrogenation/β-alkylation, followed by dehydrogenation/decarbonylation. Copyright
Bisbenzoxazines and pharmaceutical use
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, (2008/06/13)
Compounds of the formula: STR1 wherein, R is H, alkyl, cycloalkyl, aryl, or heteroaryl; R1 is H, alkyl, cycloalkyl, aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aryl, halo, OR2, SR2, NR2, CF3, NO2, CN, COOR2, CHO, SO3 H or SO2 NH2, wherein R2 is H, methyl, ethyl or propyl; Y is STR2 Z is O, S, NH or CH2 ; X is --CH2 --, STR3 or --(CH2)n CHOH(CH2)n --; wherein R2 is H, methyl, ethyl or propyl; n is 1-10, and pharmaceutically acceptable salts thereof have antiallergy and antiinflammatory activity.
THE PREPARATION OF α,ω-BIS-PARA-ANISYLALKANES
Kadkhodayan, Miryam,Singleton, Terry,Heldrich, F. J.
, p. 707 - 712 (2007/10/02)
An improved method for the preparation of a homologous series of α,ω-bis-para-anisylalkanes is described.
