488087-52-1

Upstream product

• 49629-37-0 (E)-2-(4-methoxybenzylidene)-3,4-dihydro-2H-naphthalen-1-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 134408-32-5 9-(4-chlorophenyl)-7-(4-methoxyphenyl)-6,7-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazoline 
• 99-73-0 para-bromophenacyl bromide 
• 17356-08-0 thiourea 

Relevant academic research and scientific papers

Green chemistry preparation of thiochromeno[4,3-b]pyran and benzo[h]thiazolo[2,3-b]quinazoline derivatives using HSBM technique over ZnAl2o4 nano-powders

Aim and Objective: The aim of this paper is to introduce HSBM as a green and environmentally friendly technique for the synthesis of thiochromeno[4,3-b]pyran and benzo[h]thiazolo[2,3-b]quinazoline derivatives over ZnAl2O4 nanopowders

Recyclable task-specific acidic ionic liquid [NMP]H2PO4: Microwave-assisted, efficient one-pot, two-step tandem synthesis of fused thiazolo[2,3-b]quinazolinone and thiazolo[2,3-b]quinazoline derivatives

A novel, time-effective, eco-conscious and microwave-assisted tandem one-pot, two-step reaction has been described for the synthesis of thiazolo[2,3-b]quinazolinone (4a-f) and thiazolo[2,3-b]quinazoline (5a-t) derivatives in quantitative yield in the pres

Synthesis, characterization and biological evaluation of fused thiazolo[3,2-a]pyrimidine derivatives

A series of fused thiazolo[3,2-a]pyrimidines (7a-g, 8a-f, 11a-g and 12a,b) have been synthesized in good yields by reaction of fused 3,4-dihydropyrimidin- 2(1H)-thiones (4a-g) with phenacyl bromides (5,6)/3-(2-bromoacetyl)coumarins (9,10) under conventional heating in acetic acid. Analytical and spectral studies as well as single crystal X-ray diffraction data on the representative compound 8e confirmed the structure of all the reaction products. All the synthesized compounds were screened for their antibacterial, antioxidant and DNA cleavage activities. The compound 7e against Escherichia coli, 8a and 8c-e against Pseudomonas aeruginosa have shown prominent antibacterial activity compared to the standard drug Penicillin with MIC 9.375 μg mL-1, whereas the compounds 11c, 12a and 12b have shown very good antioxidant activity compared to the standard drug Trolox with IC50 values 12.36, 11.12 and 13.88 μM respectively. Compounds 11f and 12b have completely cleaved the DNA even at 50 μg mL-1 concentration and the remaining compounds have partially cleaved the DNA.