488100-05-6Relevant academic research and scientific papers
New spiro-piperidines as 5-HT2B receptor antagonists
Bienayme, Hugues,Chene, Laurent,Grisoni, Serge,Grondin, Antonio,Kaloun, El-Bachir,Poigny, Stephane,Rahali, Houcine,Tam, Eric
, p. 4830 - 4833 (2006)
A functional screening highlighted a series of spiro-piperidines as 5-HT2B receptor antagonists. Preliminary structure-activity relationship has been explored driving to potent antagonists (IC50 = 1 nM) and indicating directions for
