488128-84-3Relevant academic research and scientific papers
AGONISTS OF THE APELIN RECEPTOR AND METHODS OF USE THEREOF
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Paragraph 0204; 0205; 0206, (2015/12/31)
Provided herein are small molecule agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions.
In vitro antifungal activity of some new triazole compounds
Chanda, Sumitra,Baluja, Shipra,Parekh, Jigna
, p. 281 - 285 (2012/11/07)
In the present study, the derivatives of 1,2,4-triazoles were synthesized and tested for antifungal activity against Candida tropicalis ATCC-4563, Candida albicans ATCC-2091, Cryptococcus neoformans ATCC-34664, Trichosporon beigelii NCIM-3404 and Aspergillus flavus NCIM-538 by disc diffusion method. 1,2,4-Triazoles were obtained by cyclization of the potassium salt of substituted dithiocarbazinic acid with hydrazine hydrate. The new synthesized compounds were characterized using IR, 1H NMR spectral data and Mass spectrometry together with elemental analysis. The inhibitory effect of the newly synthesized triazole compounds was compared to the standard antifungal agents. Minimum inhibitory concentration (MIC) was determined for those compounds which could inhibit all the tested fungal strains with maximum inhibition zone.
