4882-12-6

Upstream product

• 110-81-6 Diethyl disulfide 
• 4105-21-9 2-phenylimidazo[1,2-a]pyridine 
• 16712-69-9 p-ethylbenzenesulfonyl chloride 
• 75-08-1 ethanethiol 
• 70-11-1 α-bromoacetophenone 
• 504-29-0 2-aminopyridine 
• 352-93-2 diethyl sulphide 
• 98-86-2 acetophenone 
• 74-96-4 ethyl bromide 

Relevant academic research and scientific papers

One-pot synthesis of imidazo[1,2-α]pyridine thioethers using imidazo[1,2-α]pyridines, arylsulfonyl chlorides and hydrazine

A one-pot reaction of making RS-substituted imidazo[1,2-α]pyridine derivatives by directly using aryl or alkylsulfonyl chloride and hydrazine was developed, selectively giving good yields of the expected products. Compared with previously reported methods

Metal-Free Thiolation of Imidazopyridines with Functionalized Haloalkanes Using Elemental Sulfur

The assembly of two functional molecules via a sulfur linking atom allows an access to a diverse array of thioether-containing compounds. Herein, we disclose a metal-free thiolation of imidazopyridines with a variety of functionalized haloalkanes using elemental sulfur. (Figure presented.).

Electrochemical Oxidative C—H Sulfenylation of Imidazopyridines with Hydrogen Evolution

Selective oxidative C—H sulfenylation of imidazopyridine heterocycles is achieved using an undivided electrolytic cell. The reaction avoids the use of stoichiometric amount of external chemical oxidant and produces hydrogen gas as the only byproduct. Both

Synthesis and biological evaluation of novel benzimidazole derivatives and analogs targeting the NLRP3 inflammasome

A series of benzo[d]imidazole analogues of thiabenzole were synthesized and their anti-inflammatory activities toward NLRP3 (nucleotide-binding domain leucine-rich repeat containing protein family, pyrin domain-containing 3, also known as cryopyrin or NALP3) inflammasome were evaluated in vitro. Two lead compounds, TBZ-09 and TBZ-21, were identified by anti-production of IL-1β. In the second round of biological evaluation, based on the lead, 34 more compounds were synthesized and their in vitro anti-inflammatory activities were investigated. Several compounds were identified as anti-inflammatory agents that can reduce IL-1β expression in a dose-dependent manner. A preliminary structure-activity relationship is also summarized here.

One-Pot Three-Component Synthesis of Alkylthio-/Arylthio- Substituted Imidazo[1,2-a]pyridine Derivatives via C(sp2)–H Functionalization

Sulfenylation is an important transformation to generate C?S bonds in organic synthesis. Here, two three-component synthetic protocols have been developed by using imidazo[1,2-a]pyridine, inorganic, odorless S8 and alcohols or arylboronic acids

Cu-catalyzed sulfenylation of imidazol[1,2-: A] pyridine via C-H functionalization using a combination of Na2S2O3 and halides

A novel copper-catalysed sulfenylation method by using the inorganic salt Na2S2O3 and alkyl halides (Cl, Br, I) or iodobenzene homologues is described. The reactions proceeded smoothly, giving regioselective 2-phenylimidazo[1,2-a]pyridine thioether derivatives in good yields via a C-H functionalization process. More importantly, this method has extended the existing methods by offering a better method which can make both alkyl and aryl thioether derivatives under one set of reaction conditions.

An efficient and clean CuI-catalyzed chalcogenylation of aromatic azaheterocycles with dichalcogenides

A highly efficient and environmentally friendly method for catalytic chalcogenylation of imidazopyridines, imidazopyrimidines, indoles, and pyrrolo[2,3-b]pyridines with dichalcogenides has been developed by using CuI as catalyst under air. The reactions proceed smoothly to give the desired products in moderate to excellent yields, without the presence of other additive.