4883-65-2

Usage

Physical state

Colorless liquid

Odor

Faint

Uses

a. Production of organic compounds
b. Pharmaceutical industry
c. Dyes
d. Agrochemicals
e. Solvent in chemical reactions
f. Reagent in chemical reactions

Toxicity

Low toxicity

Safety

Follow safety precautions to minimize potential health risks when handling and using the compound.

Upstream product

• 16642-49-2 1-chloro-2-methylcyclohexene 
• 151-50-8 potassium cyanide 
• 16642-50-5 2-chloro-3-methylcyclohexene 
• 81230-79-7 (1S,2R)-2-Methyl-2-methylsulfanyl-cyclohexanecarbonitrile 
• 170233-07-5 2-methyl-1-((trimethylsilyl)oxy)cyclohexane-1-carbonitrile 
• 583-60-8 2-Methylcyclohexanone 
• 591-49-1 1-methylcyclohex-1-ene 
• 1120-72-5 2-Methylcyclopentanone 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 13148-94-2 2-methyl-1-cyclohexenecarboxylic acid 

Relevant academic research and scientific papers

Benzoic acid derivatives and related compounds as antiarrhythmic agents

Benzoic acid derivatives of the formula I where X is oxygen, sulfur, —NH, —NR1, —N—CN, —N—OR1 or —N—NO2; Y is a single bond, —C═C—, or —NH; R1 is alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocyclo, or (heterocyclo)alkyl; and R2 is aryl or heterocyclo. The compounds of formula I are useful in the treatment of arrhythmia.

Bacteriorhodopsin. The influence of the cyclohexene-ring methyls

Four ring-demethylated retinals, viz. 1,1',5-tridemethylretinal, 1,1'-didemethylretinal, 1,5-didemethylretinal and 1-demethylretinal, have been synthesized via new and simple schemes.The properties of these modified retinals, their protonated Schiff bases and the corresponding bacteriorhodopsins have been studied and compared with the native system.These bacteriorhodopsin analogues have also been tested for their proton-pump efficiencies.A large decrease in proton-pump activity was found for the analogues lacking the 5-methyl group.On the whole, the opsin shifts of the modified bacteriorhodopsins were much lower than those of the native system.UV-Vis and 1H NMR data support a planar 6-s-trans conformation for the demethylated retinals in solution rather than a twisted 6-s-cis conformation (torsion angle 40-60 deg) as found in retinal.This explains the lower opsin shift and the better fit of these demethylated retinals in bacteriorhodopsin's binding site, which, in its native form, contains a 6-s-trans chromophore.

Cyanation of 1-Halocycloalkenes Catalyzed by Tetracyanocobaltate(I). Convenient Synthesis of 1-Cyanocycloalkenes

1-Cyanocycloalkenes (1-cyanocyclopentene, -hexene, -heptene, and -octene) were readily synthesized by catalytic cyanation of the corresponding 1-halocycloalkenes with tetracyanocobaltate(I).Reactivities of methyl-substituted 1-chlorocyclohexenes were lower than that of 1-chlorocyclohexene, and 1-chloro-2-methylcyclohexene scarecely reacted.Hydrogenation and isomerization of 1-cyanocycloalkenes were observed only with 1-cyanocycloheptene and 1-cyano-6-methylcyclohexene, respectively.