488728-06-9

Upstream product

• 488727-78-2 ((2S)-ethyl-1-hydroxymethyl-allyl)-carbamic acid tert-butyl ester 
• 167102-66-1 2,2-dimethyl-(4R)-propionyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 488727-70-4 (4R)-4-(1-hydroxy-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 95715-87-0 (R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine 
• 595560-39-7 ((E)-(S)-1-{[Allyl-(2,4-dinitro-benzenesulfonyl)-amino]-methyl}-2-ethyl-but-2-enyl)-carbamic acid tert-butyl ester 
• 595560-40-0 [1-(2,4-dinitro-benzenesulfonyl)-4-ethyl-1,2,3,6-tetrahydro-pyridin-3-yl]-carbamic acid tert-butyl ester 
• 595560-31-9 tert-butyl (4R)-4-(1-ethyl-1-hydroxypropyl)-2,2-dimethyloxazolidine-3-carboxylate 
• 595560-34-2 (S)-tert-butyl 2,2-dimethyl-4-(pent-2-en-3-yl)oxazolidine-3-carboxylate 
• 595560-36-4 (S)-tert-butyl 3-ethyl-1-hydroxypent-3-en-2-ylcarbamate 
• 108149-60-6 methyl [(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]carboxylate 
• 488727-98-6 1-(2,2,2-trifluoro-acetyl)-(3S)-tert-butoxycarbonyl-amino-(4S)-ethyl-piperidine 
• 488727-86-2 ((((1S)-allyl-(2,2,2-trifluoro-acetyl)-amino)-methyl)-2-ethyl-allyl)-carbamic acid tert-butyl ester 
• 488727-82-8 toluene-4-sulfonic acid (2S)-tert-butoxycarbonylamino-3-ethyl-but-3-enyl ester 
• 488727-92-0 1-(2,2,2-trifluoro-acetyl)-(3S)-tert-butoxycarbonyl-amino-4-ethyl-1,2,3,6-tetrahydro-pyridine 

Relevant academic research and scientific papers

Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens

Novel quinolone antibacterial agents bearing (3S)-amino-(4R)-ethylpiperidines were designed by using low energy conformation analysis and synthesized by applying a conventional coupling reaction of the quinolone nuclei with new piperidine side chains. The

Synthesis of trans-(3S)-Amino-(4R)-alkyl- and -(4S)-Aryl-piperidines via Ring-Closing Metathesis Reaction

(Matrix Presented) trans-(3S)-Amino piperidines bearing various alkyl and aryl substituents at the C-4 position were synthesized via a ring-closing metathesis reaction. The absolute stereochemistry was controlled using a protected D-serine as a starting material. Stereoselective hydrogenation of allylamines provided trans-(3S)-amino-(4R)-alkyl- and -(4S)-aryl-piperidines. This procedure presents the first method for the asymmetric synthesis of 4-substituted 3-amino piperidines.