488798-40-9

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1245716-60-2 methyl 4-(4-fluorophenyl)-6-isopropyl-2-morpholinopyrimidine-5-carboxylate 
• 1307273-32-0 methyl 2-(4-nitrophenoxy)-4-(4-fluorophenyl)-6-isopropylpyrimidine-5-carboxylate 
• 160009-37-0 methyl 2-amino-4-(4-fluorophenyl)-6-isopropyl-pyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Synthesis of 2-substituted pyrimidines via cross-coupling reaction of pyrimidin-2-yl sulfonates with nucleophiles in polyethylene glycol 400

A mild and rapid procedure to the synthesis of 2-substituted pyrimidines was developed via sequential functionalization of easily available Biginelli 3,4-dihydropyrimidine-2(1H)-ones via oxidation, esterification, followed by cross-coupling reaction of pyrimidin-2-yl sulfonates with N, S, and O nucleophiles in PEG-400 as a green reaction medium at room temperature. Georg Thieme Verlag Stuttgart New York.