Synthesis of 2-substituted pyrimidines via cross-coupling reaction of pyrimidin-2-yl sulfonates with nucleophiles in polyethylene glycol 400

Article abstract of DOI:10.1055/s-0030-1258080

A mild and rapid procedure to the synthesis of 2-substituted pyrimidines was developed via sequential functionalization of easily available Biginelli 3,4-dihydropyrimidine-2(1H)-ones via oxidation, esterification, followed by cross-coupling reaction of pyrimidin-2-yl sulfonates with N, S, and O nucleophiles in PEG-400 as a green reaction medium at room temperature. Georg Thieme Verlag Stuttgart New York.