489-17-8

Basic information

• Product Name: 4-FLUORO-2-METHYL-BENZENESULFONAMIDE
• Synonyms: BenzenesulfonaMide, 4-fluoro-2-Methyl-;5-Fluoro-2-sulphamoyltoluene, 2-(Aminosulphonyl)-5-fluorotoluene;4-FLUORO-2-METHYL-BENZENESULFONAMIDE;4-FLUORO-2-METHYLBENZENESULPHONAMIDE;Benzenesulfonamide, 4-fluoro-2-methyl- (9CI)
• CAS NO: 489-17-8
• Molecular Formula: C₇H₈FNO₂S
• Molecular Weight: 189.21
• Product Categories: SULFONAMIDE;Benzene series;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds
• Mol File: 489-17-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 180-184 °C(lit.)
• Boiling Point: 324 °C at 760 mmHg
• Flash Point: 149.8 °C
• Appearance: /
• Density: 1.362 g/cm³
• Vapor Pressure: 0.000252mmHg at 25°C
• Refractive Index: 1.545
• PKA: 10.09±0.60(Predicted)
• CAS DataBase Reference: 4-FLUORO-2-METHYL-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-2-METHYL-BENZENESULFONAMIDE(489-17-8)
• EPA Substance Registry System: 4-FLUORO-2-METHYL-BENZENESULFONAMIDE(489-17-8)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 489-17-8(Hazardous Substances Data)

Usage

Uses

4-Fluoro-2-methylbenzenesulfonamide may be used to synthesize the following compounds:4-fluoro-2-methyl-N-phenylbenzenesulfonamide 4-fluoro-2-methyl-N-(m-tolyl)benzenesulfonamide N-(3-chlorophenyl)-4-fluoro-2-methylbenzenesulfonamide

InChI:InChI=1/C7H8FNO2S/c1-5-4-6(8)2-3-7(5)12(9,10)11/h2-4H,1H3,(H2,9,10,11)

Upstream product

• 7079-48-3 4-fluoro-2-methylbenzene-1-sulphonyl chloride 
• 352-70-5 m-Fluorotoluene 

Downstream Products

• 845823-04-3 4-fluoro-2-methylbenzenethiol 
• 1130322-03-0 C₂₇H₂₁ClFN₅O₄S 
• 1206111-19-4 N-(3-chloro-phenyl)-4-fluoro-2-methyl-benzenesulfonamide 
• 1206156-05-9 4-fluoro-2-methyl-N-m-tolyl-benzenesulfonamide 
• 1206137-27-0 4-fluoro-2-methyl-N-phenyl-benzenesulfonamide 
• 882852-66-6 N-[(4-fluoro-2-methylphenyl)sulfonyl]cyclohexanecaboxamide 
• 845644-47-5 1,1-dioxo-2,3-dihydrobenzo[d]isothiazol-5-yl fluoride 
• 29083-18-9 5-fluoro-1,1,3-trioxo-2,3-dihydrobenzo[d]isothiazine 

Relevant articles and documents

Preparation method and medical application of benzisothiazole and benzothiophene

The invention discloses a preparation method and medical application of benzisothiazole and benzothiophene, and telates to the field of pharmaceutical chemistry. According to the invention, benzisothiazole and benzothiophene are the first type of HIF-2 agonists; compared with a compound M1001 found by the applicant in the earlier stage, the invention has better HIF-2 agonist activity, and has remarkable enhancement activity on expression of mRNA and protein of EPO, VGEF, Glut1, NDRG1 and the like at the downstream of HIF-2, so that the invention can be used for preparing drugs for treating and/or preventing chronic kidney diseases/chronic renal anemia, dyslipidemia and high cholesterol caused by abnormal expression of HIF-2; and the method has a good industrialization prospect.

Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation

A series of 1,5-diarylpyrazoles having a substituted benzenesulfonamide moiety as pharmacophore was synthesized and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities. Through SAR and molecular modeling, it was found that fluorine substituti