7079-48-3

Basic information

• Product Name: 4-FLUORO-2-METHYLBENZENESULFONYL CHLORIDE
• Synonyms: 4-FLUORO-2-METHYLBENZENESULFONYL CHLORIDE;4-FLUORO-2-METHYLBENZENESULPHONYL CHLORIDE;4-Fluoro-o-toluenesulphonyl chloride;4-fluoro-o-toluenesulfonyl chloride;4-FLUORO-2-METHYLBENZENESULFONYL CHLORIDE 97%;4-fluoro-2-methylbenzene-1-sulfonyl chloride;2-(Chlorosulphonyl)-5-fluorotoluene
• CAS NO: 7079-48-3
• Molecular Formula: C₇H₆ClFO₂S
• Molecular Weight: 208.64
• EINECS: -0
• Product Categories: Fluoro-contained benzenesulfonyl chloride series;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds
• Mol File: 7079-48-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 245-246 °C(lit.)
• Flash Point: >230 °F
• Appearance: Colorless to yellow/Liquid
• Density: 1.433 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00539mmHg at 25°C
• Refractive Index: n20/D 1.5370
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive: Moisture Sensitive
• BRN: 6720115
• CAS DataBase Reference: 4-FLUORO-2-METHYLBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-2-METHYLBENZENESULFONYL CHLORIDE(7079-48-3)
• EPA Substance Registry System: 4-FLUORO-2-METHYLBENZENESULFONYL CHLORIDE(7079-48-3)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-27-36/37/39
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 7079-48-3(Hazardous Substances Data)

Usage

General Description

4-FLUORO-2-METHYLBENZENESULFONYL CHLORIDE is a chemical compound with the molecular formula C7H6ClFO2S. It is a sulfonamide derivative that is commonly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical products and drug intermediates. It is a white to off-white solid with a melting point of 46-49 °C. 4-FLUORO-2-METHYLBENZENESULFONYL CHLORIDE is typically used as a reagent in organic synthesis, and it is known for its ability to react with amines and alcohols to form sulfonamides and sulfonates, respectively. Additionally, it is also used as an intermediate in the production of agrochemicals and veterinary drugs.

InChI:InChI=1/C7H6ClFO2S/c1-5-4-6(9)2-3-7(5)12(8,10)11/h2-4H,1H3

Upstream product

• 352-70-5 m-Fluorotoluene 

Downstream Products

• 489-17-8 4-fluoro-2-methyl-1-benzenesulfonamide 
• 845823-04-3 4-fluoro-2-methylbenzenethiol 
• 1416131-51-5 C₂₁H₁₅ClFN₃O₃S 
• 1443468-84-5 C₂₃H₂₃FN₄O₄S 
• 1404059-65-9 N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-4-fluoro-2-methyl benzenesulfonamide 
• 1610952-19-6 1'-[2-(difluoromethoxy)benzyl]-8-[(4-fluoro-2-methylphenyl)sulfonyl]-2'H,5'H-spiro[8-azabicyclo[3.2.1]octane-3,4'-imidazolidine]-2',5'-dione 
• 82875-77-2 4-Fluoro-2-methyl-benzenesulfonic acid 2,4-dimethyl-phenyl ester 

Relevant articles and documents

Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists

The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.

Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation

A series of 1,5-diarylpyrazoles having a substituted benzenesulfonamide moiety as pharmacophore was synthesized and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities. Through SAR and molecular modeling, it was found that fluorine substituti