7079-48-3Relevant articles and documents
Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists
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, (2008/06/13)
The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.
Synthesis of fused sulfonamide (1,1-dioxoisothiazole)substituted 1,5-diarylpyrazoles as cyclooxygenase inhibitors
Pal, Manojit,Veeramaneni, Venugopal Rao,Kumar, Sanjeev,Lohray, Vidya B.,Yeleswarapu, Koteswar Rao
, p. 1095 - 1101 (2007/10/03)
First synthesis of novel 1,1-dioxo-2,3-dihydrobenzo[d] isothiazolyl substituted 1,5-diarylpyrazoles has been accomplished via oxidative cyclization of 4-fluoro-2-methyl benzenesulfonamide followed by the treatment with hydrazine and then with 1,3-dicarbon
Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation
Pal, Manojit,Madan, Manjula,Padakanti, Srinivas,Pattabiraman, Vijaya R.,Kalleda, Srinivas,Vanguri, Akhila,Mullangi, Ramesh,Mamidi, N. V. S. Rao,Casturi, Seshagiri R.,Malde, Alpeshkumar,Gopalakrishnan,Yeleswarapu, Koteswar R.
, p. 3975 - 3984 (2007/10/03)
A series of 1,5-diarylpyrazoles having a substituted benzenesulfonamide moiety as pharmacophore was synthesized and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities. Through SAR and molecular modeling, it was found that fluorine substituti