4892-23-3

Basic information

• Product Name: 3,5-dichloro-4-methoxybenzyl alcohol
• Synonyms: 3,5-dichloro-4-methoxybenzyl alcohol
• CAS NO: 4892-23-3
• Molecular Formula: C₈H₈Cl₂O₂
• Molecular Weight: 207.05392
• Mol File: 4892-23-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 308.5°C at 760 mmHg
• Flash Point: 140.4°C
• Appearance: /
• Density: 1.369g/cm³
• Vapor Pressure: 0.000293mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 3,5-dichloro-4-methoxybenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dichloro-4-methoxybenzyl alcohol(4892-23-3)
• EPA Substance Registry System: 3,5-dichloro-4-methoxybenzyl alcohol(4892-23-3)

Safety Data

• Hazardous Substances Data: 4892-23-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8Cl2O2/c1-12-8-6(9)2-5(4-11)3-7(8)10/h2-3,11H,4H2,1H3

Upstream product

• 17302-82-8 ethyl 3,5-dichloro-4-hydroxybenzoate 
• 24295-27-0 methyl 3,5-dichloro-4-methoxybenzoate 

Downstream Products

• 41727-58-6 3,5-dichloro-4-methoxybenzaldehyde 
• 441284-62-4 (Z)-2,6-dichloro-4-(1'-propenyl)anisole 
• 109047-54-3 (3,5-dichloro-4-methoxy-phenyl)-acetic acid 
• 98588-81-9 (3,5-dichloro-4-methoxy-phenyl)-acetonitrile 
• 27164-02-9 (3,5-dichloro-4-methoxy-phenyl)-acetic acid amide 
• 249757-10-6 [(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetonitrile 
• 193073-55-1 [(S)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester 
• 3336-41-2 3,5-dichloro-4-hydroxybenzoic acid 
• 37908-97-7 3,5-dichloro-4-methoxybenzoic acid 
• 98544-66-2 4-bromomethyl-2,6-dichloro-anisole 
• 1027152-07-3 1-[4-(methylsulfonyl)phenyl]-2-(4-methoxy-3,5-dichlorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole 
• 3336-38-7 3,5-dichloro-4-methyloxybenzonitrile 

Relevant articles and documents

Novel imidazole derivatives with anti-inflammatory activity

Novel imidazole derivatives of formula I and their salts, solvates and prodrugs, wherein the meanings of the different radicals are as shown in the description. Said compounds are useful as anti-inflammatory agents.

Synthesis of (1R,2S)-1-(3′-chloro-4′-methoxyphenyl)-1,2- propanediol (trametol) and (1R,2S)-1-(3′,5′-dichloro-4′- methoxyphenyl)-1,2-propanediol, chlorinated fungal metabolites in the natural environment

(1R,2S)-1-(3′-Chloro-4′-methoxyphenyl)-1,2-propanediol (Trametol, 3), a metabolite of the fungus Trametes sp. IVP-F640 and Bjerkandera sp. BOS55, was synthesized by employing Sharpless asymmetric dihydroxylation as the key step. Similarly, the (1R,2S)-isomer of 1-(3′,5′-dichloro- 4′-methoxyphenyl)-1,2-propanediol (4), another metabolite of Bjerkandera sp. BOS55, was synthesized by asymmetric dihydroxylation.

1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents

Series of 1,2-diarylimidazoles has been synthesized and found to contain highly potent and selective inhibitors of the human COX-2 enzyme. The paper describes a short synthesis of the target 1,2-diarylimidazoles starting with aryl nitriles. Different portions of the diarylimidazole (I) were modified to establish SAR. Systematic variations of the substituents in the aryl ring B have yielded very potent (IC50 = 10-100 nm) and selective (1000-12500) inhibitors of the COX-2 enzyme. The study on the influence of substituents in the imidazole ring established that a CF3 group at position 4 gives the optimum oral activity. A number of the diarylimidazoles showed excellent inhibition in the adjuvant induced arthritis model (e.g., ED50 = 0.02 mpk for 22 and 34). The diarylimidazoles are also potent inhibitors of carrageenan-induced edema (ED50 = 9-30 mpk) and hyperalgesia (ED50 = 11- 40 mpk). Several orally active diarylimidazoles show no GI toxicity in the rat and mouse up to 200 mpk.