41727-58-6

Usage

Uses

Used in Herbicide Industry:
3,5-Dichloro-4-methoxybenzoic acid is used as a herbicide for its ability to inhibit the enzyme protoporphyrinogen oxidase, which is essential for plant growth. This property makes it an effective agent in controlling unwanted vegetation.
Used in Pharmaceutical Industry:
3,5-Dichloro-4-methoxybenzoic acid is used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. Its unique chemical structure allows it to be a key component in the development of new drugs and medications.
It is important to handle 3,5-Dichloro-4-methoxybenzoic acid with care, as it may cause irritation to the skin, eyes, and respiratory system if not properly managed.

InChI:InChI=1S/C8H6Cl2O2/c1-12-8-6(9)2-5(4-11)3-7(8)10/h2-4H,1H3

Upstream product

• 4892-23-3 3,5-dichloro-4-methoxybenzyl alcohol 
• 2314-36-5 3,5-dichloro-4-hydroxybenzaldehyde 
• 74-88-4 methyl iodide 
• 24295-27-0 methyl 3,5-dichloro-4-methoxybenzoate 

Downstream Products

• 3336-38-7 3,5-dichloro-4-methyloxybenzonitrile 
• 213470-64-5 (+/-)-1-(3',5'-dichloro-4'-methoxyphenyl)-1-propanol 
• 37908-97-7 3,5-dichloro-4-methoxybenzoic acid 
• 249757-10-6 [(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetonitrile 
• 441284-62-4 (Z)-2,6-dichloro-4-(1'-propenyl)anisole 
• 213470-65-6 1-(3',5'-dichloro-4'-methoxyphenyl)-1-propanone 
• 213470-68-9 1-(3,5-Dichloro-4-methoxy-phenyl)-2-hydroxy-propan-1-one 
• 95333-57-6 1-(3,5-Dichloro-4-hydroxy-benzyl)-1,3-dihydro-imidazole-2-thione 
• 105764-05-4 1-(3,5-Dichloro-4-methoxy-benzyl)-1,3-dihydro-imidazole-2-thione 
• 80751-56-0 2-[2-(2-Chloro-3,4-dimethoxy-phenyl)-ethylamino]-1-(3,5-dichloro-4-methoxy-phenyl)-ethanol 
• 540779-07-5 ethyl (E)-3,5-dichloro-4-methoxycinnamate 
• 867070-07-3 9-(3,5-dichloro-4-methoxyphenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one 

Relevant academic research and scientific papers

SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS

The present invention relates generally to substituted isoquinolines and their use as tubulin polymerization inhibitors. In particular, the invention relates to substituted isoquinolines which possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds

Novel imidazole derivatives with anti-inflammatory activity

Novel imidazole derivatives of formula I and their salts, solvates and prodrugs, wherein the meanings of the different radicals are as shown in the description. Said compounds are useful as anti-inflammatory agents.

Induction of apoptosis in cancer cells

The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of cancer or for treating disease conditions caused by apoptosis of cells.

Compositions containing aromatic aldehydes and their use in treatments

Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.

Synthesis of (1R,2S)-1-(3′-chloro-4′-methoxyphenyl)-1,2- propanediol (trametol) and (1R,2S)-1-(3′,5′-dichloro-4′- methoxyphenyl)-1,2-propanediol, chlorinated fungal metabolites in the natural environment

(1R,2S)-1-(3′-Chloro-4′-methoxyphenyl)-1,2-propanediol (Trametol, 3), a metabolite of the fungus Trametes sp. IVP-F640 and Bjerkandera sp. BOS55, was synthesized by employing Sharpless asymmetric dihydroxylation as the key step. Similarly, the (1R,2S)-isomer of 1-(3′,5′-dichloro- 4′-methoxyphenyl)-1,2-propanediol (4), another metabolite of Bjerkandera sp. BOS55, was synthesized by asymmetric dihydroxylation.

Chlorometabolite production by the ecologically important white rot fungus Bjerkandera adusta

Two strains of the basidiomycete, Bjerkandera adusta (DAOM 215869 and BOS55) produce in static liquid culture, phenyl, veratryl, anisyl and chloroanisyl metabolites (CAM's) (alcohols, acids and aldehydes) as well as a series of compounds not previously known to be produced by Bjerkandera species: 1-phenyl, 1-anisyl, 1-(3-chloro-4-methoxy) and 1-(3,5-dichloro-4-methoxy) propan-1,2-diols, predominantly as erythro diastereomers with 1R, 2S absolute configurations. 1-Anisyl-propan-1,2-diol and 1-(3,5-dichloro-4-methoxy)-propan-1,2-diol are new metabolites for which the names Bjerkanderol A and B, respectively, are proposed. Experiments with static liquid cultures supplied with 13C66- and 13C9-L-phenylalanine showed that all identified aromatic compounds (with the exception of phenol) can be derived from L-phenylalanine. For the aryl propane diols, the 13C label appeared only in the phenyl ring and the benzylic carbon, suggesting a stereoselective re-synthesis from a C7 and a C2-unit, likely aromatic aldehyde and decarboxylated pyruvate, respectively. Other compounds newly discovered to be derived from phenylalanine by this white rot fungus include phenylacetaldehyde and phenylpyruvic, phenylacetic, phenyllactic, mandelic and phenyl glyoxylic (benzoyl formic) acids. For both strains, cultures supplied with Na37Cl showed incorporation of 37Cl in all identified chlorometabolites. Veratryl alcohol and the CAM alcohols, which occur in both strains and can be derived from L-phenylalanine (all 13C-labelled), have reported important physiological functions in this white rot fungus. Possible mechanisms for their formation through the newly discovered compounds are discussed.

Synthetic studies towards the synthesis of western and eastern chloropeptin I, II subunits

The western subunit (16-membered ring) was synthesized by the intramolecular SNAr reaction while the first 16-membered ring compound was obtained as a model of the eastern subunit via an intramolecular Ni0 mediated coupling reaction.

1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents

Series of 1,2-diarylimidazoles has been synthesized and found to contain highly potent and selective inhibitors of the human COX-2 enzyme. The paper describes a short synthesis of the target 1,2-diarylimidazoles starting with aryl nitriles. Different portions of the diarylimidazole (I) were modified to establish SAR. Systematic variations of the substituents in the aryl ring B have yielded very potent (IC50 = 10-100 nm) and selective (1000-12500) inhibitors of the COX-2 enzyme. The study on the influence of substituents in the imidazole ring established that a CF3 group at position 4 gives the optimum oral activity. A number of the diarylimidazoles showed excellent inhibition in the adjuvant induced arthritis model (e.g., ED50 = 0.02 mpk for 22 and 34). The diarylimidazoles are also potent inhibitors of carrageenan-induced edema (ED50 = 9-30 mpk) and hyperalgesia (ED50 = 11- 40 mpk). Several orally active diarylimidazoles show no GI toxicity in the rat and mouse up to 200 mpk.