489446-77-7 Usage
Uses
Used in Pharmaceutical Industry:
Cetilistat is utilized as a therapeutic agent for the treatment of obesity. It operates by inhibiting the activity of pancreatic lipase, an enzyme responsible for the breakdown of fat in the intestine. By blocking this enzyme, cetilistat reduces the absorption of dietary fat, which contributes to weight loss in obese patients. (2R,4S)-4-AMINO-1-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCl is typically administered orally in tablet form, making it a convenient treatment option for obesity management.
Check Digit Verification of cas no
The CAS Registry Mumber 489446-77-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,8,9,4,4 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 489446-77:
(8*4)+(7*8)+(6*9)+(5*4)+(4*4)+(3*6)+(2*7)+(1*7)=217
217 % 10 = 7
So 489446-77-7 is a valid CAS Registry Number.
489446-77-7Relevant academic research and scientific papers
Synthesis and DNA binding properties of saturated distamycin analogues
Woods, Craig R.,Faucher, Nicolas,Eschgfaller, Bernd,Bair, Kenneth W.,Boger, Dale L.
, p. 2647 - 2650 (2007/10/03)
A series of saturated heterocyclic analogues of distamycin were prepared and examined. A fluorescent intercalator displacement (FID) assay conducted on p[dA]-p[dT] DNA to obtain C50 values and a hairpin deoxyoligonucleotide containing an A/T-rich binding site was used to evaluate DNA binding affinity. It is observed that saturated heterocycles greatly reduce the DNA binding relative to distamycin.
